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Fig. 4 | Molecular Autism

Fig. 4

From: Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation

Fig. 4

Effects of chronic treatment with rapamycin on TSC2 neuronal activity. Raster (upper panels) and ASDR plots (lower panels) of a single neuronal MEA culture at 60 DPP in the absence (A) and presence of rapamycin (10 nM) (B). Vertical-scale bar = 200 spikes per 200 ms bin. Underneath show changes in a basal excitability, b synchronised burst (SB) activity and the number of spikes in individual SB, c SB length and interval and d spikes firing outside of a SB. All plots show means ± SEM. *p < 0.05 following unpaired t tests. Number of recorded wells = 6

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Molecular Autism

ISSN: 2040-2392