Fig. 2

The first row shows the scatterplot of the main CCA mode of the brain structural covariations versus the symptom profiles for CCA₁ and CCA₂ respectively. One dot per participant in each graph is coded with gradient colors according to the scores of ADOS RRB (a) and SSP (b), respectively. The second row shows the histograms of the null distribution of correlation values obtained from the main CCA mode at 10,000 random participants’ permutations in the autism sample with ADI and ADOS scores (c), and with SRS, RBS, and SSP scores (d). The true r-value is marked by a red cross. ADI, Autism Diagnostic Interview-Revised; ADOS, Autism Diagnostic Observational Schedule 2; SRS, Social Responsiveness Scale 2nd Edition; RBS, Repetitive Behavior Scale-Revised; SSP, Short Sensory Profile; RRB, restricted and repetitive behaviors