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Fig. 1 | Molecular Autism

Fig. 1

From: High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons

Fig. 1

Symmetric copy number variations at 7q11.23. a Schematic representation of genotype–phenotype correlation in WBS and 7Dup patients, compared to healthy control (CTL), indicating opposite and shared phenotypes. Genomic organization of WBS region with the 17 genes that are significantly expressed in neurons, in bold the four genes selected for their critical role in the pathogenesis of both WBS and 7Dup. b Lentiviral vector (top) and PiggyBac-based construct (bottom) used to induce iPSC differentiation into cortical neurons. Ubc: human Ubiquitin constitutive promoter, rtTA: TET transactivator promoter gene, NGN2: Neurogenin2 gene, PuroR: Puromycin resistance gene, BsdR: Blasticidin resistance gene, white triangles represent terminal repeats of the transposon

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Molecular Autism

ISSN: 2040-2392