Fig. 3
From: Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus
Mapping the Shank3 binding site on δ-catenin. a The domain structure of δ-catenin, and the truncated proteins used in this study. The Armadillo repeats are indicated in red and the binding sites for N-cadherin and PDZ ligands as well as the phosphorylation and palmitoylation sites are indicated by arrows. b GFP-tagged fragments of δ-catenin were coexpressed with RFP-tagged full-length Shank3. Cells were lysed and GFP-tagged proteins were immunoprecipitated using the GFP-trap matrix. Input and IP samples were analysed by Western blotting. The results show that the Arm repeats of δ-catenin bind to Shank3