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Fig. 1 | Molecular Autism

Fig. 1

From: Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome

Fig. 1

Successful maternal Ube3a gene activation upon Nestin-Cre-mediated deletion of the transcriptional STOP cassette. a, b Western blot data and UBE3A quantification from total lysates of E9 and E15 brains of Ube3amLSL+, Ube3amLSL/− mice, and WT littermates normalized to WT E15 levels. Bars depict mean ± SD (n = 2 per genotype, per time point). c, d DAB and immunofluorescent pictures of UBE3A expression in sections of brains from adult wild-type, Ube3amLSL/Cre+ and Ube3amLSL/Cre mice

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