Table 2 Summary of phenotypes in Chd8 haploinsufficient mouse lines
From: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life
This study | Platt et al. | Katayama et al. | Gompers et al. | Suetterlin et al. | Jung et al. | |
|---|---|---|---|---|---|---|
Age range tested (weeks) | 25–52 | 10–14 | 13–17 | 8–16 | 9–12 | 8–14 |
Body weight | Decrease (25 weeks) | Decrease (10 weeks) | No change (9 weeks) | No change | Decrease (5 weeks) | No change (3 weeks) |
Brain weight or volume at birth | Increase | X | Increase | Increase | Increase | X |
Pup survival, reared by Chd8 mutant dams | Reduced | X | X | X | X | X |
Elevated plus maze | ||||||
% open arm time | No change | X | Decrease | X | X | No change |
Open field | ||||||
Total distance | No change | Decrease | No change | No change | Decrease | Decrease |
Rearing | Decrease | X | X | X | X | X |
Center time | Decrease | Decrease | Decrease | X | No change | Decrease |
Three chamber test | ||||||
Sociability | No change | No change | No change | No change | Increase | No change |
Novelty preference | Increase | Decrease | Decrease | X | X | No change |
Entries | No change | No change | X | No change | X | X |
Marble-bury assay | No change | No change | X | No change | Decrease | No change |
Acoustic startle | ||||||
Amplitude | No change | X | Decrease | X | X | X |
Prepulse inhibition | No change | X | Increase | X | X | No change |
Olfactory test | No change | X | X | X | X | No change |