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Table 2 Summary of phenotypes in Chd8 haploinsufficient mouse lines

From: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

  This study Platt et al. Katayama et al. Gompers et al. Suetterlin et al. Jung et al.
Age range tested (weeks) 25–52 10–14 13–17 8–16 9–12 8–14
Body weight Decrease (25 weeks) Decrease (10 weeks) No change (9 weeks) No change Decrease (5 weeks) No change (3 weeks)
Brain weight or volume at birth Increase X Increase Increase Increase X
Pup survival, reared by Chd8 mutant dams Reduced X X X X X
Elevated plus maze
 % open arm time No change X Decrease X X No change
Open field
 Total distance No change Decrease No change No change Decrease Decrease
 Rearing Decrease X X X X X
 Center time Decrease Decrease Decrease X No change Decrease
Three chamber test
 Sociability No change No change No change No change Increase No change
 Novelty preference Increase Decrease Decrease X X No change
 Entries No change No change X No change X X
Marble-bury assay No change No change X No change Decrease No change
Acoustic startle
 Amplitude No change X Decrease X X X
 Prepulse inhibition No change X Increase X X No change
Olfactory test No change X X X X No change
  1. X indicates not conducted or not reported. Consult the indicated references for details as methodological differences may affect or limit comparisons between studies