Fig. 4
From: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life
Open-field behaviors as a function of age. WT and Chd8V986*/+ male mice were tested at (a, c, and e) 6 months of age and at (b, d, f) 12 months of age. a, b Distance traveled. No significant differences. c, d Number of rears. Six-month-old [genotype × time interaction, F(11,154) = 2.36, p = 0.01] and 1-year-old [main effect of genotype, F(1,14) = 10.0, P = 0.0069] Chd8V986*/+ mice showed a significant decrease in rearing movements relative to age-matched WT controls. e, f Time in center. No significant differences between 6-month-old WT and Chd8V986*/+ mice [genotype × time interaction, F(11,154) = 1.83, p = 0.0536]. Twelve-month-old Chd8V986*/+ mice showed a significant reduction in center time behavior relative to age-matched WT controls [genotype × time interaction, F(11,154) = 2.91, p = 0.0016]. Lines and shaded areas represent means ± S.E.M. Each data point represents an individual mouse. *p < 0.05, **p < 0.01, ***p < 0.001