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Fig. 1 | Molecular Autism

Fig. 1

From: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

Fig. 1

Increased brain weight at birth in Chd8V986*/+ haploinsufficient mice. a ASD-linked mutations in human CHD8. The mouse CHD V986* mutation is synonymous with human CHD8 V984* (boxed). The region recognized by the CHD8 antibody (Ab) is shown. b Western blot and c quantification of CHD8 protein (290 kDa) in brain lysates from WT and Chd8V986*/+ mice; age P0. Data represents mean of 3–6 samples per genotype ± S.E.M., **P < 0.01. WT: wild-type; Mut: Chd8V986*/+. d, e Body and brain weights of WT and Chd8V986*/+ mice at P0. Data are mean of 17–20 samples per genotype ± S.E.M. *P < 0.05; ***P < 0.001

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