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Fig. 4 | Molecular Autism

Fig. 4

From: Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B

Fig. 4

MSC-exo can cross the BBB and integrate into the cells in the tissue. a Complete sagittal section of Shank3B KO shows MSC-exo are found in the parenchyma and accumulate mainly in the area of the cortex, cerebellum, and some accumulation in the hippocampus (96 h post intranasal administration). b Complete sagittal section of WT shows complete evacuation of MSC-exo from the brain (96 h post intranasal administration). c, d Magnification of the cerebellum and hippocampus tissues of Shank3B KO shows MSC-exo are found in the tissue. e Magnification of the CA1 area with DAPI (blue), PKH26 exosomes (red), and astrocytes (GFAP green)

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