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Table 1 Summary of neurodevelopmental disorders modeled using cerebral organoids. Several studies have identified cellular phenotypes of neurodevelopmental disorders using organoids. Here, we summarize the organoid model used, the phenotypes found, and the age at which they were detected

From: Cerebral organoids as tools to identify the developmental roots of autism

Disorder Mutation Organoid type Time-point(s) analyzed Cellular phenotype identified Reference
Microcephaly CDK5RAP2+/− Cerebral 30 days Imbalance of symmetrical/asymmetrical division [78]
ASD Idiopathic Cerebral 44 days FOXG1 overexpressed in ASD [89]
ASD CDH8+/− Cerebral 50 days Dysregulation of neurogenesis associated genes [149]
Miller-Dieker syndrome 17p13.3 del Cerebral 45 days Reduced migration [6]
Timothy syndrome CACNA1C, GoF Forebrain assembloid 80 days Migration and depolarization defects [9]
Angelman syndrome UBE3A−/− Cortical 120-150 days Hyperexcitability and synchronous firing [139]
Schizophrenia, autism DISC1+/− Cortical sliced 120 days Lamination defects [120]
  1. GoF gain of function, del deletion