Fig. 4
Recovery of a subset of ASD-associated expression patterns after treatment with IGF-1. a MA-plot of differential expression between neurons derived from either neurotypical controls (CTL) or ASD individuals both in baseline (H2O) conditions. logCPM log counts per million, logFC log fold-change. Red dots = genes p-adj < 0.05, grey dots = genes p-adj > 0.05. Numbers in the top and bottom corners indicate the number of genes (transcripts) differentially expressed with a logFC > 0 (higher expression in controls) or logFC < 0 (higher expression in ASD). b Correlation plot of the logFC between ASD and CTL (x-axis) and the logFC between ASD samples in H2O and after acute (top) or chronic (bottom) IGF-1 treatment. c Gene overlap between acute and chronic conditions for genes that are recovered by IGF-1 treatment as plotted in panel b. d Top genes recovered by IGF-1 acute and/or chronic treatment