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Fig. 9 | Molecular Autism

Fig. 9

From: Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences

Fig. 9

Expression of glutamate receptor subunit in the CPu of control and VPA-exposed rats treated or not with fenofibrate. The levels of expression of NR1, NR2A, and NR2B subunits of AMPA receptor and GluR1 subunit of NMDA receptor were measured in the CPu by immunoblotting in male (ad) and female rats (fi). a Two-way ANOVA, VPA exposure: F1,25 = 0.80, n.s.; FBR administration: F1,25 = 0.75, n.s.; interaction: F1,25 = 3.05, n.s. b Two-way ANOVA, VPA exposure: F1,25 = 0.09, n.s.; FBR administration: F1,25 = 0.11, n.s.; interaction: F1,25 = 0.03, n.s. c Two-way ANOVA, VPA exposure: F1,25 = 15.22, p = 0.0006; FBR administration: F1,25 = 3.82, n.s.; interaction: F1,25 = 0.06, n.s. d Two-way ANOVA, VPA exposure: F1,20 = 0580, n.s.; FBR administration: F1,20 = 0.15, n.s.; interaction: F1,20 = 0.46, n.s. e Representative immunoblotting of NR1, NR2A, NR2B, and GluR1 in male. f Two-way ANOVA, VPA exposure: F1,20 = 4.31, n.s.; FBR administration: F1,20 = 1.18, n.s.; interaction: F1,20 = 0.79, n.s. g Two-way ANOVA, VPA exposure: F1,20 = 0.16, n.s.; FBR administration: F1,20 = 0.69, n.s.; interaction: F1,20 = 1.61, n.s. h Two-way ANOVA, VPA exposure: F1,20 = 1.81, n.s.; FBR administration: F1,20 = 4.30, n.s.; interaction: F1,20 = 7.72, p = 0.0116; post hoc comparison: #p < 0.05 vs. VPA-SD group. i Two-way ANOVA, VPA exposure: F1,20 = 0.93, n.s.; FBR administration: F1,20 = 2.86, n.s.; interaction: F1,20 = 3.65, n.s. j Representative immunoblotting of NR1, NR2A, NR2B, and GluR1 in female rats. Values are expressed as mean ± SEM and calculated as percentage of the respective saline-SD group values; n = 6–8

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