Fig. 6

VPA-exposed male rats showed increased anxiety in the elevated plus maze test. VPA-exposed male rats showed a reduction of the percentage of time spent in the open arm (a) and an increase of the percentage of time spent in the closed arm (b). a Two-way ANOVA, VPA exposure: F_{1, 44} = 6.69, p = 0.013; FBR administration: F_{1, 44} = 1.09, n.s.; interaction: F_1,44 = 3.02, n.s. b Two-way ANOVA, VPA exposure: F_{1, 44} = 4.41, p = 0.0413; FBR administration: F_{1, 44} = 1.46, n.s.; interaction: F_1,44 = 0.21, n.s. Values are expressed as mean ± SEM of the percentage of time spent in the open or closed arm divided by the total time in open + closed arms; n = 12. VPA exposure did not affect anxiety behavior in female rats (c, d). c Two-way ANOVA, VPA exposure: F_{1, 43} = 0.54, n.s.; FBR administration F_{1, 43} = 3.21, n.s.; interaction: F_1,43 = 0.42, n.s. d Two-way ANOVA, VPA exposure: F_{1, 43} = 0.69, n.s.; FBR administration: F_{1, 43} = 3.21, n.s.; interaction: F_1,43 = 0.59, n.s. Values are expressed as mean ± SEM of the percentage of time spent in the open or closed arm divided by the total time in open + closed arms; n = 12. *p < 0.05 main effect of VPA exposure