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Table 1 Participant demographics and global brain measures

From: Neuroanatomical underpinnings of autism symptomatology in carriers and non-carriers of the 22q11.2 microdeletion

  22q11.nonASD 22q11.ASD ASD Controls Test statistic
(n = 25 [11♂, 14♀]) (n = 25 [13♂, 12♀]) (n = 40 [32♂, 8♀]) (n = 41 [23♂, 18♀]) χ2 p
IoPPN/UCLA/Frankfurt 8/17/0 17/8/0 0/0/40 14/14/13 105.03 < 0.001
          F p
Age [years] 14 ± 6 (6–25) 15 ± 4 (7–23) 15 ± 2 (11–18) 14 ± 4 (7–24) 0.18 0.91
Full-scale IQ 86 ± 15 (60–116) 81 ± 12 (61–112) 96 ± 13 (64–116) 104 ± 11 (76–123) 21.01 < 0.001
ADI-R social1 5 ± 3 (1–9) 19 ± 5 (9–28) 17 ± 4 (9–27) n/a n/a 95.93 < 0.001
ADI-R communication1 6 ± 4 (0–16) 14 ± 4 (8–24) 13 ± 4 (5–23) n/a n/a 29.98 < 0.00
ADI-R repetitive1 1 ± 2 (0–8) 3 ± 3 (0–10) 5 ± 2 (1–10) n/a n/a 16.8 < 0.001
ADOS CSS1 3 ± 2 (1–8) 6 ± 3 (1–10) 6 ± 3 (1–10) n/a n/a 9.3 < 0.001
SRS total score 55 ± 26 (16–103) 101 ± 33 (41–174) 95 ± 29 (42–159) 23 ± 19 (0–75) 69.38 < 0.001
SRS repetitive 9 ± 6 (1–22) 17 ± 7 (7–32) 16 ± 7 (0–34) 2 ± 3 (0–10) 49.31 < 0.001
Total cortical volume [L] 0.66 ± 0.08 (0.41–0.89) 0.68 ± 0.07 (0.52–0.78) 0.75 ± 0.07 (0.60–0.92) 0.73 ± 0.07 (0.59–0.90) 10.56 < 0.001
Total surface area [m2] 0.20 ± 0.02 (0.13–0.25) 0.21 ± 0.02 (0.17–0.24) 0.23 ± 0.02 (0.18–0.27) 0.22 ± 0.02 (0.19–0.27) 12.41 < 0.001
Mean cortical thickness [mm] 2.78 ± 0.13 (2.59–3.06) 2.77 ± 0.10 (2.60–2.96) 2.71 ± 0.10 (2.51–2.93) 2.71 ± 0.10 (2.48–3.01) 3.74 < 0.05
  1. Data expressed as mean ± standard deviation (range); (1) data based on 89 individuals
  2. ADI-R Autism Diagnostic Interview-Revised, ADOS Autism Diagnostic Observation Schedule, CCS Calibrated Severity Score, SRS Social Responsiveness Scale