Table 4 Models showing the relationships of clinical severity measures with TBV within the CHOP ASD group only. No severity measure showed a significant relationship with ASD symptoms, controlling for age, sex, and IQ
From: Evidence against the “normalization” prediction of the early brain overgrowth hypothesis of autism
Clinical severity and total brain volume | |||||||||
|---|---|---|---|---|---|---|---|---|---|
SRS | ADOS CSS | SCQ | |||||||
B | Std. Beta | p | B | Std. Beta | p | B | Std. Beta | p | |
(Intercept) | 1202.68 | < .001 | 1193.05 | < .001 | 1165.85 | < .001 | |||
IQ | 0.3 | 0.05 | 0.382 | 0.28 | 0.05 | 0.417 | 0.39 | 0.07 | 0.252 |
Age | − 2.4 | − 0.07 | 0.224 | − 2.26 | − 0.07 | 0.255 | − 1.36 | − 0.04 | 0.499 |
Sex | 93.88 | 0.43 | < .001 | 91.27 | 0.42 | < .001 | 91.99 | 0.44 | < .001 |
SRS | − 0.45 | − 0.05 | 0.37 | ||||||
ADOS CSS | − 0.43 | − 0.01 | 0.893 | ||||||
SCQ | 0.17 | 0.01 | 0.883 | ||||||
Observations | 234 | 238 | 233 | ||||||
R2/adj. R2 | .192/.178 | .184/.170 | .199/.185 | ||||||