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Table 4 Models showing the relationships of clinical severity measures with TBV within the CHOP ASD group only. No severity measure showed a significant relationship with ASD symptoms, controlling for age, sex, and IQ

From: Evidence against the “normalization” prediction of the early brain overgrowth hypothesis of autism

Clinical severity and total brain volume
 SRSADOS CSSSCQ
 BStd. BetapBStd. BetapBStd. Betap
(Intercept)1202.68 < .0011193.05 < .0011165.85 < .001
IQ0.30.050.3820.280.050.4170.390.070.252
Age− 2.4− 0.070.224− 2.26− 0.070.255− 1.36− 0.040.499
Sex93.880.43< .00191.270.42< .00191.990.44< .001
SRS− 0.45− 0.050.37      
ADOS CSS   − 0.43− 0.010.893   
SCQ      0.170.010.883
Observations234238233
R2/adj. R2.192/.178.184/.170.199/.185