Table 2 Models for primary sample. Uncorrected p-values are reported. One outlier was removed from the lateral ventricle model.
From: Evidence against the “normalization” prediction of the early brain overgrowth hypothesis of autism
CHOP Models | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Predictors | Estimates | std. Beta | p | partial η2 | Estimates | std. Beta | p | partial η2 | Estimates | std. Beta | p | partial η2 |
TBV | GMV | WMV | ||||||||||
Intercept | 1034.67 | -0.35 | <0.001 | 0.69 | 698.45 | -0.34 | <0.001 | 0.77 | 337.69 | -0.29 | <0.001 | 0.48 |
IQ | 1.52 | 0.25 | <0.001 | 0.07 | 0.90 | 0.25 | <0.001 | 0.08 | 0.62 | 0.20 | <0.001 | 0.04 |
Age | -1.80 | -0.06 | 0.143 | 0.00 | -6.13 | -0.33 | <0.001 | 0.15 | 4.29 | 0.27 | <0.001 | 0.09 |
Sex | 85.43 | 0.73 | <0.001 | 0.20 | 48.28 | 0.69 | <0.001 | 0.21 | 37.13 | 0.62 | <0.001 | 0.15 |
Diagnosis | -206.92 | -0.25 | <0.001 | 0.05 | -130.81 | -0.27 | <0.001 | 0.07 | -75.89 | -0.17 | <0.001 | 0.03 |
IQ*Diagnosis | 1.67 | 0.28 | <0.001 | 0.04 | 1.05 | 0.29 | <0.001 | 0.05 | 0.62 | 0.20 | 0.001 | 0.02 |
R2 / R2 adjusted | 0.290 / 0.282 | 0.377 / 0.370 | 0.280 / 0.272 | |||||||||
Cortical GMV | Cortical WMV | |||||||||||
Intercept | 532.98 | -0.33 | <0.001 | 0.72 | 314.27 | -0.30 | <0.001 | 0.47 | ||||
IQ | 0.75 | 0.25 | <0.001 | 0.07 | 0.61 | 0.21 | <0.001 | 0.05 | ||||
Age | -5.66 | -0.36 | <0.001 | 0.17 | 3.80 | 0.26 | <0.001 | 0.08 | ||||
Sex | 38.27 | 0.64 | <0.001 | 0.18 | 35.57 | 0.63 | <0.001 | 0.16 | ||||
Diagnosis | -112.55 | -0.26 | <0.001 | 0.07 | -72.09 | -0.17 | <0.001 | 0.03 | ||||
IQ*Diagnosis | 0.91 | 0.30 | <0.001 | 0.06 | 0.59 | 0.20 | 0.001 | 0.02 | ||||
R2 / R2 adjusted | 0.370 / 0.363 | 0.276 / 0.268 | ||||||||||
Cerebellum | Cerebellar GMV | Cerebellar WMV | ||||||||||
Intercept | 128.62 | -0.27 | <0.001 | 0.66 | 105.20 | -0.27 | <0.001 | 0.68 | 23.42 | -0.15 | <0.001 | 0.35 |
IQ | 0.13 | 0.17 | <0.001 | 0.03 | 0.11 | 0.19 | <0.001 | 0.04 | 0.02 | 0.06 | 0.178 | 0.00 |
Age | 0.01 | 0.00 | 0.929 | 0.00 | -0.48 | -0.16 | <0.001 | 0.03 | 0.49 | 0.37 | <0.001 | 0.14 |
Sex | 8.50 | 0.58 | <0.001 | 0.12 | 6.94 | 0.59 | <0.001 | 0.13 | 1.57 | 0.31 | <0.001 | 0.04 |
Diagnosis | -15.91 | -0.23 | 0.004 | 0.02 | -12.11 | -0.26 | 0.005 | 0.02 | -3.80 | -0.08 | 0.046 | 0.01 |
IQ*Diagnosis | 0.12 | 0.16 | 0.020 | 0.01 | 0.09 | 0.14 | 0.029 | 0.01 | 0.03 | 0.12 | 0.065 | 0.01 |
R2 / R2 adjusted | 0.176 / 0.167 | 0.213 / 0.204 | 0.189 / 0.180 | |||||||||
Lateral Ventricles | Third Ventricles | GMV:WMV Ratio | ||||||||||
Intercept | 7.28 | -0.04 | <0.001 | 0.03 | 0.75 | -0.05 | <0.001 | 0.14 | 1.93 | 0.05 | <0.001 | 0.87 |
IQ | -0.01 | -0.02 | 0.669 | 0.00 | -0.00 | -0.00 | 0.993 | 0.00 | -0.00 | -0.02 | 0.564 | 0.00 |
Age | 0.28 | 0.19 | <0.001 | 0.03 | 0.00 | 0.01 | 0.827 | 0.00 | -0.03 | -0.67 | <0.001 | 0.46 |
Sex | 0.49 | 0.08 | 0.288 | 0.00 | 0.03 | 0.12 | 0.119 | 0.01 | -0.02 | -0.13 | 0.033 | 0.01 |
Diagnosis | -0.83 | -0.14 | 0.042 | 0.01 | 0.09 | -0.20 | 0.148 | 0.00 | -0.01 | -0.05 | 0.334 | 0.00 |
Age*Diagnosis | -0.01 | -0.16 | 0.017 | 0.01 | ||||||||
R2 / R2 adjusted | 0.049 / 0.040 | 0.040 / 0.029 | 0.464 / 0.459 | |||||||||