Fig. 5
From: Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
Volcano plot all days and network analysis. a Volcano plot demonstrating proteins differentially expressed in RTT versus iCTR after pooling all time points of neuronal development. The x-axis represents the log2-fold change in abundance (RTT/iCTR) and y-axis the − log10 (p value). Threshold for significant proteins is chosen for p value cutt-off (0.1) and fold change ≤ 1.3. Upregulated proteins in RTT are shown in red, and downregulated are shown in blue. b GO analysis on the biological process of the significant proteins. X-axis represents the − log10 (p value), and red and blue colors indicate for up- and downregulated proteins in RTT, respectively. The numbers represent the genes enriched for each term. c Reactome pathway analysis of the significant proteins. d Network analysis of the significant proteins by Cytoscape plugin GeneMania. Red indicates for upregulated, and blue indicates for downregulated proteins in RTT