Fig. 1
From: Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD
Three domains for future expansion of iPSC studies. Increases in the number of patient iPSCs within a study (from low to high); assay complexity (from single parameter of 2D cultures to complex, multi-parameteric, high content assays on co-cultures or in 3D structured and organoid conditions) and increases in cell genetic complexity (from single CNV (monogenic) to multiple CNV and increasing polygenic (PRS) genomic background)