Skip to main content

Table 1 Membrane properties of Nkx2.1 interneurons and pyramidal cells

From: Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice

Properties Interneurons Pyramidal cells
  Control (n = 9) Tg (n = 12) Control (n = 5) Tg (n = 11)
Vm (mV) − 57.7 ± 1.6 − 60.5 ± 2.2 − 66.5 ± 1.3 − 67.2 ± 0.8
AP threshold (mV) − 41.6 ± 1 − 41.8 ± 1.5 − 47.2 ± 1.7 − 49.9 ± 0.8
AP half-width (ms) 0.42 ± 0.05 0.33 ± 0.03 0.9 ± 0.1 0.7 ± 0.02
AP amplitude (mv) 67.2 ± 3 67.7 ± 6.2 100.9 ± 4.6 96.3 ± 1.2
AHP amplitude (mV) − 25.7 ± 1 − 22.1 ± 2.3 − 7.7 ± 1.2 − 9 ± 0.9
  1. Control Nkx2.1Cre/wt;Tsc1wt/wt, Tg Nkx2.1Cre/wt;Tsc1f/wt, Vm resting membrane potential, AP action potential, AHP afterhyperpolarization