Skip to main content

Table 1 Membrane properties of Nkx2.1 interneurons and pyramidal cells

From: Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice

PropertiesInterneuronsPyramidal cells
 Control (n = 9)Tg (n = 12)Control (n = 5)Tg (n = 11)
Vm (mV)− 57.7 ± 1.6− 60.5 ± 2.2− 66.5 ± 1.3− 67.2 ± 0.8
AP threshold (mV)− 41.6 ± 1− 41.8 ± 1.5− 47.2 ± 1.7− 49.9 ± 0.8
AP half-width (ms)0.42 ± 0.050.33 ± 0.030.9 ± 0.10.7 ± 0.02
AP amplitude (mv)67.2 ± 367.7 ± 6.2100.9 ± 4.696.3 ± 1.2
AHP amplitude (mV)− 25.7 ± 1− 22.1 ± 2.3− 7.7 ± 1.2− 9 ± 0.9
  1. Control Nkx2.1Cre/wt;Tsc1wt/wt, Tg Nkx2.1Cre/wt;Tsc1f/wt, Vm resting membrane potential, AP action potential, AHP afterhyperpolarization