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Table 5 Adverse events

From: Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

Event Severity Intervention relationshipa Expected # Participants
Blood analyses
 Leukocytopenia Mild 2-3 Yes 1
 Hypokalemia Mild 1-2 Yes 7
 Hyponatremia Mild 2 Yes 1
 Hypovolemia Mild 1 Yes 1
Gastrointestinal symptoms
 Nausea/vomiting Mild 3 Yes 1
 Obstipation Mild 2 Yes 2
 Decreased appetite Mild 2 No 1
 Weight loss Mild 2 Yes 1
Genitourinary
 Diuresis Mild 1 Yes 1
Infections
 Viral infection Mild 3 No 1
 Urinary tract infection Mild 2 No 1
Behavioral symptoms
 Aggression Moderate 2 No 2
 Irritability Mild 2 No 2
 Anxiety Mild 2 No 1
Musculoskeletal     1
 Medial malleolus fracture Moderate 3 No 1
 Humerus fracture Moderate 3 No 1
Other
 Hypotension Mild 1 Yes 1
 Hypothermia Mild 3 No 1
 Dehydration Mild 1 Yes 1
 Palpitations Mild 2 No 1
  1. Note: a1: Definitely related; 2: Possibly related; 3: Not related