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Table 5 Adverse events

From: Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

EventSeverityIntervention relationshipaExpected# Participants
Blood analyses
 LeukocytopeniaMild2-3Yes1
 HypokalemiaMild1-2Yes7
 HyponatremiaMild2Yes1
 HypovolemiaMild1Yes1
Gastrointestinal symptoms
 Nausea/vomitingMild3Yes1
 ObstipationMild2Yes2
 Decreased appetiteMild2No1
 Weight lossMild2Yes1
Genitourinary
 DiuresisMild1Yes1
Infections
 Viral infectionMild3No1
 Urinary tract infectionMild2No1
Behavioral symptoms
 AggressionModerate2No2
 IrritabilityMild2No2
 AnxietyMild2No1
Musculoskeletal   1
 Medial malleolus fractureModerate3No1
 Humerus fractureModerate3No1
Other
 HypotensionMild1Yes1
 HypothermiaMild3No1
 DehydrationMild1Yes1
 PalpitationsMild2No1
  1. Note: a1: Definitely related; 2: Possibly related; 3: Not related