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Table 2 Habituation and percentage prepulse-pulse inhibition (PPI)

From: Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

 

TD (n = 31)

TSC (n = 7)

Time point

D0

D0

D91

D119

Trial

Mean % (SD)

Mean % (SD)

85dB/120ms

34 (33)

-9 (52)

19 (25)c

1 (55)

85dB/60ms

30 (35)

-13 (45)

-15 (16)

-12 (45)

76dB/120ms

32 (27)ab

-24 (58)

13 (30)

3 (21)

76dB/60ms

13 (49)ab

-44 (55)

-26 (34)

-14 (20)

Habituation coefficient

-4.52

-1.91

-6.63ac

-.78ac

  1. Abbreviations: TD typically developing controls, TSC tuberous sclerosis complex
  2. asignificant after Bonferroni correction; bgroup effect; ctreatment effect