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Fig. 1 | Molecular Autism

Fig. 1

From: Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders

Fig. 1

Current research in ASD. Current ASD research focuses on genetic sequencing studies to identify ASD risk genes, based on the enrichment of single nucleotide or copy number variations. Following identification, post-mortem brains from individuals with ASD are used for analysis of the proteome or transcriptome, and single genes are studied using animal models. Animal models are studied in vivo and in vitro for changes in neuron morphology and activity as well as in the transcriptome and proteome. Post-mortem brains are limited in availability and do not provide insight into the early developmental time points directly, while animal models only study one gene at a time, resulting in the low throughput elucidation of disease-relevant mechanisms for only a minority of ASD-risk genes

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