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Fig 6 | Molecular Autism

Fig 6

From: Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Fig 6

Morphological analyses of the dendritic tree of Pvalb neurons in the hippocampal DG (ac), striatum (df), and MLI (gi) of PV-EGFP and PVKO-EGFP mice. a Representative images (EGFP fluorescence) of a DG Pvalb neuron of both genotypes. b 3D-reconstruction of the same neurons using the Imaris software. c Quantitative assessment of number of branches on 1st–5th order dendrites. For all images: ns not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. d Representative images (EGFP fluorescence) of striatal Pvalb neurons of both genotypes. e 3D-reconstruction of the same neurons using the Imaris software. f Quantitative assessment of length of dendrites from 1st to 5th order branches. g Representative images (EGFP fluorescence) of MLI of both genotypes. h 3D-reconstruction of the same neurons using the Imaris software. i Quantitative assessment of thickness of primary dendrites at a distance of 10, 15, 20, 25, and 30 μm away from the soma

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