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Fig. 2 | Molecular Autism

Fig. 2

From: Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Fig. 2

Co-staining for PV (red), EGFP (green), and DAPI (blue) in 8 different brain regions from PV-EGFP and PVKO-EGFP mice. In sections from PV-EGFP mice, note complete co-localization (yellow cells in the merged images) of PV and EGFP in regions with high PV expression levels (mPFC, SSC, striatum, TRN, and cerebellum). In all hippocampal regions (CA1, CA3, DG), a fraction of green (EGFP) cells show weak-to-absent PV staining (red) and green (only) cells (arrowheads) are seen in the merged images indicative of generally low PV expression levels in hippocampal Pvalb neurons. Yet the higher sensitivity for EGFP allows to identify those low-PV Pvalb neurons. The density and morphology of Pvalb cells (evidenced by EGFP staining) is qualitatively similar in all investigated regions in PV-EGFP (left) and PVKO-EGFP (right) mice. Scale bars: mPFC, SSC, and striatum 30 μm, CA1, CA3, DG, TRN, and cerebellum 50 μm

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Molecular Autism

ISSN: 2040-2392