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Fig. 5 | Molecular Autism

Fig. 5

From: TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

Fig. 5

Transcriptome analysis of TSC1 NPCs reveals genotype-dependent changes in gene expression. a–c Differential expression analysis identified distinct and shared upregulated and downregulated genes in the isogenic TSC1 NPC set for Het or 2 independent Null clones (a, b) versus Corr-WT. d Of the 107 genes shared between Het and Null NPCs, 29 showed a genotype-dependent linear response (showed on the heat map: e). This subset included ASD-related genes (red, up; blue, down) as well as multiple members of the Zinc-finger gene family of transcription factors (*). f Gene ontology analysis for the genes that showed a linear response

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Molecular Autism

ISSN: 2040-2392