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Table 5 Normalized inactivation kinetic parameters of mutation S652W

From: Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder

 Remaining ICa [%]
α1-subunitr50r100r250r500r1000r5000n
WTL60.45 ± 4.2247.88 ± 4.0930.88 ± 3.2120.44 ± 2.2614.61 ± 1.857.59 ± 0.8611
S652WL62.86 ± 2.3449.49 ± 2.3531.35 ± 2.1320.61 ± 1.9913.85 ± 1.536.35 ± 0.7413
  1. r values represent the fraction of remaining ICa after 50, 100, 250, 500, 1000, and 5000 ms upon a 5-s depolarization to the voltage of maximal inward current (Vmax). All values are presented as meanM (> 3 independent transfections). No significant differences were found by unpaired Student’s t test of r values, compared to WTL. n, number of recordings; WT, wild-type