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Table 4 Activation and inactivation parameters of mutation S652W

From: Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder

 ActivationInactivation
α1-subunitV0.5 (mV)k (mV)Vrev (mV)nV0.5,inact (mV)k (mV)Non-inactivating (%)n
WTL− 0.50 ± 1.489.32 ± 0.2667.1 ± 1.6019− 17.5 ± 1.325.94 ± 0.2817.4 ± 1.4516
S652 WL4.23 ± 1.27*8.73 ± 0.2264.6 ± 2.1219− 13.1 ± 1.22*5.73 ± 0.3015.1 ± 1.0613
  1. Parameters were obtained by fitting normalized activation curves (G/Gmax) or inactivation curves (I/Icontrol) as in Table 1. All values are presented as mean ± SEM (> 3 independent transfections). Statistics: unpaired Student’s t test, *p < 0.05 compared to WTL. n, number of recordings. V0.5, half maximal activation/inactivation voltage; Vrev, reversal potential; WT, wild- type