Skip to main content

Table 4 Activation and inactivation parameters of mutation S652W

From: Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder

 

Activation

Inactivation

α1-subunit

V0.5 (mV)

k (mV)

Vrev (mV)

n

V0.5,inact (mV)

k (mV)

Non-inactivating (%)

n

WTL

− 0.50 ± 1.48

9.32 ± 0.26

67.1 ± 1.60

19

− 17.5 ± 1.32

5.94 ± 0.28

17.4 ± 1.45

16

S652 WL

4.23 ± 1.27*

8.73 ± 0.22

64.6 ± 2.12

19

− 13.1 ± 1.22*

5.73 ± 0.30

15.1 ± 1.06

13

  1. Parameters were obtained by fitting normalized activation curves (G/Gmax) or inactivation curves (I/Icontrol) as in Table 1. All values are presented as mean ± SEM (> 3 independent transfections). Statistics: unpaired Student’s t test, *p < 0.05 compared to WTL. n, number of recordings. V0.5, half maximal activation/inactivation voltage; Vrev, reversal potential; WT, wild- type
Back to article page

Molecular Autism

ISSN: 2040-2392