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Table 3 Tail current parameters of mutation S652L

From: Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder

α1-subunitτfast (ms)τslow (ms)C (pA/pF)Afast (pA/pF)Aslow (pA/pF)Half width (ms)Norm. tail area (pA*ms)n
− 60 mV
WTL0.16 ± 0.010.91 ± 0.08− 0.003 ± 0.001− 0.79 ± 0.02− 0.12 ± 0.020.31 ± 0.02− 0.44 ± 0.0214
S652LL0.20 ± 0.01*0.81 ± 0.04− 0.007 ± 0.001**− 0.51 ± 0.02***− 0.37 ± 0.03***0.41 ± 0.02***− 0.65 ± 0.03***16
− 40 mV
WTL0.19 ± 0.021.12 ± 0.07− 0.006 ± 0.001− 0.65 ± 0.02− 0.24 ± 0.010.37 ± 0.02− 0.65 ± 0.0414
S652LL0.39 ± 0.03***1.95 ± 0.08***− 0.047 ± 0.003***− 0.29 ± 0.02***− 0.54 ± 0.02***0.92 ± 0.07***− 1.87 ± 0.09***16
  1. Normalized tail currents were fitted to a bi-exponential decay (τfast, τslow: time constants of slow and fast component; Afast, Aslow: amplitudes of slow and fast components; C: non-inactivating component). Statistics: Mann-Whitney U test, *p < 0.05, **p < 0.01, ***p < 0.001. All values are presented as mean ± SEM (> 3 independent transfections). n, number of recordings