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Fig. 8 | Molecular Autism

Fig. 8

From: Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder

Fig. 8

Mutation S652L shows higher isradipine sensitivity. Concentration–response curves for WTL and S652LL steady-state ICa inhibition by isradipine. Data are presented as mean ± SEM for the n-numbers indicated. Curves were fitted using a Hill slope = 1 and top-bottom fixed (bottom = 0; top = 100). IC50 values are given as means with 95% confidence interval. The statistical significance was determined using the extra sum-of-squares F test (p < 0.0001).

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