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Fig. 5 | Molecular Autism

Fig. 5

From: Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons

Fig. 5

Within-family analysis of transcriptomic signatures specific to the affected proband-derived samples. a Venn diagram for the cExN NPCs, showing the DEGs from pairwise comparisons of different samples, including numbers of overlapping DEGs. The blue shaded portion of the Venn diagram indicates DEGs unique to the AP, not shared by the IS or UM. b-d Ingenuity Pathway Analysis (IPA) of the AP-unique DEGs in cExN NPCs defined (b) class and function-associated GO terms and identified gene networks associated with (c) ‘behavior’ and (d) ‘nervous system development and function’. e-h IPA analysis of the AP-unique DEGs in cIN NPCs determined (f) class and function-associated GO terms and identified gene networks associated with (g) ‘behavior’ and (h) ‘nervous system development and function’. Within each network, red symbols indicate upregulated genes and green symbols indicate downregulated genes, where the color intensity represents the relative degree of differential expression

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