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Fig. 5 | Molecular Autism

Fig. 5

From: The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

Fig. 5

Activation of FA pathway in HNs. Representative western blot panels and blot analysis of phospho-FAK/ FAK (a), phospho-SRC/ SRC (b), talin (c), vinculin (d), and zyxin (e) levels, in WT (white) and AS (grey) HNs in control, Noco-treated (dotted) and Bleb-treated (striped columns) conditions. Results are reported in % in respect to WT levels: a *P < 0.05 WT vs. AS and AS vs. AS+Noco, Bonferroni’s selected pair test; b *P < 0.05 AS+Noco vs. WT and vs. AS, Bonferroni’s test; within AS HNs: °°P < 0.01 AS vs. AS+Noco and vs. AS+Bleb, Bonferroni’s test; c *P < 0.05 WT vs. AS, Bonferroni’s selected pair test; e *P < 0.05 WT vs. AS; Bonferroni’s test; f scheme of FA cluster and intracellular signaling. N ≥ 5 for control conditions, n ≥ 3 for treated conditions

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