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Fig. 4 | Molecular Autism

Fig. 4

From: Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference

Fig. 4

Stimulus pair retention and transitive inference is intact in Nlgn3−/y and Nlgn3R451C mice. Performance accuracy (% correct responses) on the 4 premise pairs during a pseudorandom integration (stage 4, last 5 sessions) and b transitive inference test session. a Relative to A+B, B+C: p < 0.001, aMD = − 0.205, 95% CI = − 0.254, − 0.156; C+D: p < 0.001, aMD = − 0.082, 95% CI = − 0.121, − 0.043). C+D greater than B+C (p < 0.001, aMD = 0.123, 95% CI = 0.082, 0.165. D+E marginally higher than A+B (p = 0.043, aMD = 0.045, 95% CI = 0.001, 0.088. B B+C compared to all other pairs (A+B: p = 0.007, aMD = − 0.25, 95% CI = − 0.432, − 0.068; C+D: p = 0.002, aMD = − 0.25, 95% CI = − 0.410, − 0.090; D+E: p < 0.001, aMD = − 0.375, 95% CI = − 0.582, − 0.168). Median regression with genotype and stimulus pair as independent variables, and each animal treated as a cluster. b See Additional file 1: Table S7 for statistics. c Accuracy on A>E (non-transitive) and B>D (transitive) during transitive inference test (dotted line indicates chance performance; AE>chance t(57) = 22.44, p < 0.001; BD>chance t(57) = 3.98, p < 0.001). Data points plotted for each mouse, data represent median ± 95% CI. # denotes significant difference between stimulus pairs (#p < 0.05, ##p < 0.01, a = lower than A+B, b = higher than B+C, c = higher than A+B-); * denotes significant difference from chance (50% accuracy) (*p < 0.05, **p < 0.01)

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