Table 2 PMS patients with neuropsychiatric decompensation and atrophy on brain imaging
Case | Age at imaging | Imaging technique | Findings | Proposed diagnosis on review |
|---|---|---|---|---|
2 | 27 y | CT | Diffuse mild cortical atrophy and hydrocephalus ex vacuo | Bipolar disorder with catatonia |
10 | 12 y | MRI | Diffuse cerebral and cerebellar atrophy | Metachromatic leukodystrophy |
11 | 52 y | CT | Cerebral atrophy, with multiple intracranial meningiomas | Bipolar disorder with catatonia, neurofibromatosis type 2 |
22 | 45 y | MRI | Normal, except for mild enlargement of the cisterna magna and central atrophy | Progressive neurological disorder |
26 | 19, 25, and 41 y | CT | Corticosubcortical atrophy | Bipolar disorder |
28 | 43 y | CT | Mild corticosubcortical atrophy | Bipolar disorder |
31 | 70 y | MRI | Cortical atrophy, particularly in the frontal region, and subtle periventricular white matter changes | Bipolar disorder with catatonia |
43 | NA (between 20 and 46 y) | NA | Cerebral and cerebellar atrophy | Unspecified psychotic disorder with catatonia |
45 | 42 y | MRI | Discrete loss of cerebral tissue predominantly in the left hemisphere with enlarged sulci | Bipolar disorder |
56 | NA (between 23 and 30 y) | MRI | Incipient cortical atrophy | Bipolar disorder with catatonia |