Fig. 1

Age of onset of regression or emergent psychiatric phenotypes. For each patient report where the onset of regression or the emergence of psychiatric phenotypes was clearly documented, we noted the age and summed the number of individuals in each bin. We omitted all cases without such information. Cases with onset in “late adolescence” or “late teens” were included in the 16–20 years bin (see Table 1). For those cases with a 2-year window of onset (i.e., 9–10 and 12–13), we used the later time point. Females and males were counted together but identified by differing colors