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Table 1 Demographic characteristics of children and their parents in the MARBLES study, stratified by child diagnosis

From: A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood

 

Child 36 month outcome

ASD (n = 41)

Non-TD (n = 44)

TD (n = 77)

p valuea

Child male gender, n (%)

30 (73.2)

27 (61.4)

40 (51.9)

0.08

Child race and ethnicity, n (%)

   

0.90

 White (European or Middle Eastern)

19 (46.3)

18 (40.9)

38 (49.4)

 

 Black/African-American

2 (4.9)

2 (4.5)

1 (1.3)

 

 Asian or Pacific Islander

4 (9.8)

3 (6.8)

7 (9.1)

 

 Hispanic White

8 (19.5)

11 (25)

19 (24.7)

 

 Hispanic Non-White

4 (9.8)

3 (6.8)

6 (7.8)

 

 Multiracial

4 (9.8)

7 (15.9)

6 (7.8)

 

Mother age (years), mean (SD)b

35.4 (5.1)

34.1 (4.3)

33.3 (4.9)

0.09

Father age (years), mean (SD)c

38.7 (5.3)

36.1 (4.8)

35.7 (6.2)

0.02 k

Mother prepregnancy BMI, mean (SD)d

27.9 (7.4)

29.3 (8.3)

26.1 (6.2)

0.05

Mother type 1 diabetes, n (%)e

0 (0)

0 (0)

1 (1.3)

1.00

Mother type 2 diabetes, n (%)e

0 (0)

0 (0)

1 (1.3)

1.00

Mother gestational diabetes, n (%)f

12 (30)

6 (14.3)

11 (14.7)

0.12

Mother hypertension, n (%)e

1 (2.6)

1 (2.3)

1 (1.3)

1.00

Mother preeclampsia, n (%)g

2 (5.1)

4 (10)

2 (2.7)

0.29

Mother smoking by urine cotinine, n (%)h

4 (17.4)

1 (4.3)

1 (2.9)

0.12

Mother bachelor’s degree +, n (%)

18 (43.9)

19 (43.2)

40 (51.9)

0.57

Father bachelor’s degree +, n (%)

21 (51.2)

19 (43.2)

39 (50.6)

0.69

Own home, n (%)i

21 (55.3)

25 (58.1)

48 (63.2)

0.69

Cesarean delivery, n (%)j

11 (26.8)

17 (38.6)

31 (41.3)

0.28

Gestational age (weeks), mean (SD)

39.4 (1.1)

39 (1.3)

38.7 (1.4)

0.04 k

Birth weight (kg), mean (SD)

3.5 (0.4)

3.5 (0.4)

3.4 (0.5)

0.52

  1. ASD autism spectrum disorder, Non-TD non-typically developing, TD typically developing
  2. ap values from Fisher’s exact test for categorical variables and one-way ANOVA for continuous variables
  3. bFrequency missing = 1 ASD
  4. cFrequency missing = 2 ASD, 1 TD
  5. dFrequency missing = 1 ASD, 1 TD
  6. eFrequency missing = 2 ASD, 1 Non-TD, 1 TD
  7. fFrequency missing = 1 ASD, 2 Non-TD, 2 TD
  8. gFrequency missing = 2 ASD, 4 Non-TD, 2 TD
  9. hFrequency missing = 18 ASD, 21 Non-TD, 42 TD
  10. iFrequency missing = 3 ASD, 1 Non-TD, 1 TD
  11. jFrequency missing = 2 TD
  12. kNominally-significant association with child diagnosis