Fig. 3
Identification and functional enrichment of Non-TD-associated differentially expressed genes in cord blood. Gene expression in umbilical cord blood samples from subjects with typical development (TD, n = 120, 59 male/61 female) or those diagnosed with Non-TD at age 3 (n = 92, 50 male/42 female) was assessed by expression microarray. SVA was performed to control for technical and biological variables including sex and array batch. Differential expression analysis was carried out separately by study and combined in a meta-analysis. a Identification of 66 differentially expressed genes in meta-analysis (66 probes, log2(fold change) > 0.1, p < 0.01). b Fold change in gene expression for top 20 differentially expressed genes by meta-analysis log2(fold change) for individual studies and meta-analysis. c Non-TD-associated differentially expressed genes were analyzed for functional enrichment in recently evolved genes with WebGestalt using the hypergeometric test. Significantly enriched clades are shown (FDR q < 0.05). d Non-TD-associated differentially expressed genes specific to primates are listed