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Fig. 1 | Molecular Autism

Fig. 1

From: A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood

Fig. 1

Identification and function of ASD-associated differentially expressed genes in cord blood from two high-risk prospective studies. Gene expression in umbilical cord blood samples from subjects with typical development (n = 120, 59 male/61 female) or those diagnosed with ASD at age 36 months (n = 59, 43 male/16 female) was assessed by expression microarray. SVA was performed to control for technical and biological variables including sex and array batch. Differential expression analysis was carried out separately by study and combined in a meta-analysis. a Identification of 172 differentially expressed genes in meta-analysis (178 probes, log2(fold change) > 0.1, p < 0.01). b Fold change in gene expression for top 20 differentially expressed genes sorted by meta-analysis log2(fold change) and plotted for individual studies and meta-analysis. c ASD-associated differentially expressed genes were analyzed for functional enrichment with WebGestalt using the hypergeometric test and compared to all genes annotated to the array. Significantly enriched ontology terms are shown (FDR q < 0.05). d ASD-associated differentially expressed genes belonging to significantly enriched ontology terms are listed

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