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Fig. 4 | Molecular Autism

Fig. 4

From: Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism

Fig. 4

a Structure of AT Hook: DNA complex (left panel) represented in ribbon diagram (PDBID: 2EZD). AT Hook motif in pink interacts with the minor groove of DNA in salmon. AT Hook motif in lemon of PHF21A was modeled (middle panel) based on the PDBID: 2EZD. The mutated AT Hook (Gly429Ser) motif in marine was similarly modeled (right panel) based on the PDBID: 2EZD. b Superposition of the modeled structure of AT Hook region in native form (Gly) and in mutated form (Ser). The presence of serine in the mutated form creates a charge repulsive environment, which is not conducive to protein-DNA interaction

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Molecular Autism

ISSN: 2040-2392