RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation

Table 1 Discordant group differentially expressed genes at FDR < 20%. For each gene, the estimated fold change, average expression (in log counts per million), p value and FDR adjusted p values from edgeR are given. The final column indicates if the gene showed a consistent direction of differential expression across all twin pairs and the arrow which direction this was in (increased or decreased expression in ASC affected compared to unaffected co-twin)

ensembl gene id	hgnc symbol	chr	logFC	logCPM	P value	FDR	cons. dir
ENSG00000211892	IGHG4	14	2.1483	1.9484	2.11E-08	3.76E-04
ENSG00000126860	EVI2A	17	− 0.6581	5.1208	2.88E-06	1.94E-02	↓
ENSG00000207445	SNORD15B	11	− 0.8524	3.0638	3.28E-06	1.94E-02	↓
ENSG00000150681	RGS18	1	− 0.5252	6.9877	2.49E-05	1.11E-01	↓
ENSG00000139679	LPAR6	13	− 0.6090	4.7990	3.46E-05	1.23E-01	↓
ENSG00000163682	RPL9	4	− 0.6645	6.8391	5.01E-05	1.48E-01
ENSG00000163736	PPBP	4	− 0.4830	7.4291	6.32E-05	1.60E-01	↓
ENSG00000035499	DEPDC1B	5	− 1.3113	0.5493	1.00E-04	1.86E-01	↓
ENSG00000187534	PRR13P5	19	1.5220	0.4947	1.14E-04	1.86E-01
ENSG00000198339	HIST1H4I	6	− 0.6694	3.7498	1.15E-04	1.86E-01	↓
ENSG00000156482	RPL30	8	− 0.5020	8.3615	1.18E-04	1.86E-01	↓
ENSG00000229117	RPL41	12	− 0.5682	6.9233	1.28E-04	1.86E-01	↓
ENSG00000166710	B2M	15	− 0.5655	11.3125	1.44E-04	1.86E-01	↓
ENSG00000138180	CEP55	10	− 1.4366	0.2429	1.48E-04	1.86E-01
ENSG00000184825	HIST1H2AH	6	− 0.7410	3.6227	1.61E-04	1.86E-01
ENSG00000145425	RPS3A	4	− 0.7436	6.8823	1.67E-04	1.86E-01

ISSN: 2040-2392