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Table 3 SRS sub-scale score comparison stratified by genotype, ASD status, and sex

From: Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry

 

Social awareness

Social cognition

Social communication

Social motivation

RRB

SCI

Mean ± SD

p value

Mean ± SD

p value

Mean ± SD

p value

Mean ± SD

p value

Mean ± SD

p value

Mean ± SD

p value

Genotype

Control

47.04 ± 8.88

45.27 ± 7.64

45.88 ± 8.14

46.13 ± 7.66

47.66 ± 8.51

45.50 ± 7.74

3q29Del

67.33 ± 13.28

1.45E− 13

69.06 ± 15.51

1.20E− 15

69.69 ± 13.92

< 2.00E− 16

62.10 ± 13.52

1.62E− 10

77.31 ± 14.25

< 2.00E− 16

69.52 ± 14.63

< 2.00E− 16

Sex

Male control

45.97 ± 9.15

45.23 ± 7.42

45.73 ± 6.34

46.57 ± 6.58

47.63 ± 5.59

45.37 ± 6.60

Male 3q29Del

69.92 ± 13.92

7.61E− 09

71.08 ± 17.65

1.07E− 08

72.12 ± 15.47

1.74E− 10

63.92 ± 15.23

3.39E− 06

79.92 ± 14.82

2.84E− 13

72.00 ± 16.34

7.12E− 10

Female control

48.27 ± 8.56

45.31 ± 8.03

46.04 ± 9.95

45.62 ± 8.85

47.69 ± 11.08

45.65 ± 9.01

Female 3q29Del

64.27 ± 12.08

4.52E− 06

66.68 ± 12.51

1.29E− 08

66.82 ± 11.52

2.99E− 08

59.95 ± 11.14

1.36E− 05

74.23 ± 13.22

1.30E− 09

66.59 ± 12.02

1.87E− 08

ASD Status

Control

47.04 ± 8.88

45.27 ± 7.64

45.88 ± 8.14

46.13 ± 7.66

47.66 ± 8.51

45.50 ± 7.74

No ASD diagnosis 3q29Del

62.61 ± 13.20

5.17E− 09

64.10 ± 15.80

5.77E− 11

64.61 ± 13.54

1.20E− 12

58.00 ± 13.15

1.42E− 06

70.58 ± 11.50

< 2.00E− 16

64.13 ± 14.39

5.19E− 12

ASD diagnosis 3q29Del

75.94 ± 8.33

2.43E− 15

78.12 ± 10.18

< 2.00E− 16

78.94 ± 9.18

< 2.00E− 16

69.59 ± 10.99

5.12E− 12

89.59 ± 10.04

< 2.00E− 16

79.35 ± 9.02

< 2.00E− 16

  1. Comparison of mean scores on the SRS sub-scales between study participants with 3q29Del and controls. 3q29Del participants were stratified by ASD status and sex for further analysis. p values were calculated using simple linear regression, adjusting for age, race, and sex