Fig. 5
From: Mechanisms underlying the EEG biomarker in Dup15q syndrome
Paternal Dup15q syndrome PSDs and scalp topographies. a PSDs derived from all 19 channels (spatially interpolated from HD EEG) show prominent beta peaks in a 13-year-old boy with a paternal duplication (ID: 801-005). b Reference cohort PSDs were reconstructed using a simple linear regression model, plugging in the log age of 801-005 (161 months). Channel-averaged PSD derived from 801-005 shows higher beta power at all frequency bins than the Dup15q reference cohort 95% confidence interval of the mean. The channel-averaged peak beta frequency is lower in 801-005 (f = 20.4 Hz) as compared with the reference cohort (f = 23.3 Hz). c Violin plot of power at the reference cohort peak frequency (f = 23.3 Hz, reconstructed power), with 801-005 indicated in yellow near the top of the distribution. d PSDs derived from all 19 channels (clinical EEG) show prominent beta peaks in an 8-year-old girl with a paternal duplication (ID: 801-015). e Reference cohort PSDs were reconstructed using a simple linear regression model, plugging in the log age of 801-015 (96 months). Channel-averaged PSD derived from 801-015 shows beta power largely in the range of the Dup15q reference cohort 95% confidence interval. The channel-averaged peak beta frequency is lower in 801-015 (f = 19.7 Hz) as compared with the reference cohort (f = 23.1 Hz). f Violin plot of power at the reference cohort peak frequency (f = 23.1 Hz, reconstructed power), with 801-015 indicated in yellow near the mean of the distribution. g 801-005 beta power scalp topography measured at f = 23.3 Hz (reference cohort reconstructed power peak frequency). h Dup15q syndrome reference cohort beta power scalp topography measured at the group level peak frequency f = 23.3 Hz (reconstructed power from 801-005 regression model). i 801-015 beta power scalp topography measured at 23.1 Hz (reference cohort reconstructed power peak frequency). j Dup15q syndrome reference cohort beta power scalp topography measured at the group level peak frequency f = 23.1 Hz (reconstructed power from 801-015 regression model)