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Table 4 Relationship between intellectual functioning (corrected) scores, and autism features, with FMR1 mRNA levels in FM-only males with incomplete FMR1 mRNA silencing and PM/FM mosaic males

From: Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features

  FM-only with incomplete FMR1 mRNA silencing PM/FM mosaic
n β ± se p n β ± se p
Intellectual functioning
 cVIQ 32 14.7 ± 38.7 0.705 12 13.6 ± 4.52 0.003*
 cPIQ 32 13.5 ± 25.3 0.594 13 14.8 ± 3.77 < 0.001*
 cFSIQ 32 6.75 ± 27.6 0.807 12 9.62 ± 4.28 0.025*
Autism features
 ADOS CSS 29 − 0.78 ± 0.77 0.310 12 − 0.85 ± 0.87 0.331
 SA CSS 29 − 0.60 ± 0.98 0.538 12 − 0.79 ± 1.04 0.448
 RRB CSS 29 − 0.92 ± 0.96 0.338 12 − 1.16 ± 0.65 0.074
  1. Robust regression was used to conduct analysis, without adjustment for any covariate. *p value remained < 0.05 after adjustment for multiple testing
  2. Italic values indicate significance prior to adjustment for multiple testing