Skip to main content

Table 4 Relationship between intellectual functioning (corrected) scores, and autism features, with FMR1 mRNA levels in FM-only males with incomplete FMR1 mRNA silencing and PM/FM mosaic males

From: Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features

 

FM-only with incomplete FMR1 mRNA silencing

PM/FM mosaic

n

β ± se

p

n

β ± se

p

Intellectual functioning

 cVIQ

32

14.7 ± 38.7

0.705

12

13.6 ± 4.52

0.003*

 cPIQ

32

13.5 ± 25.3

0.594

13

14.8 ± 3.77

< 0.001*

 cFSIQ

32

6.75 ± 27.6

0.807

12

9.62 ± 4.28

0.025*

Autism features

 ADOS CSS

29

− 0.78 ± 0.77

0.310

12

− 0.85 ± 0.87

0.331

 SA CSS

29

− 0.60 ± 0.98

0.538

12

− 0.79 ± 1.04

0.448

 RRB CSS

29

− 0.92 ± 0.96

0.338

12

− 1.16 ± 0.65

0.074

  1. Robust regression was used to conduct analysis, without adjustment for any covariate. *p value remained < 0.05 after adjustment for multiple testing
  2. Italic values indicate significance prior to adjustment for multiple testing
Back to article page

Molecular Autism

ISSN: 2040-2392