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Table 3 Relationship between intellectual functioning (corrected) scores and autism features, with FMR1 mRNA levels in males and females

From: Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features

  Males Females
n β ± se p n β ± se p
Intellectual Functioning (corrected)a
 cVIQ 66 9.09 ± 3.90 0.023* 28 10.6 ± 6.18 0.087
 cPIQ 67 8.71 ± 4.77 0.072 28 2.85 ± 4.68 0.543
 cFSIQ 66 9.46 ± 4.24 0.029* 28 5.32 ± 4.50 0.237
Autism featuresb
 ADOS CSS 59 0.12 ± 0.25 0.627 25 − 8.00 ± 0.69 0.249
 SA CSS 59 0.52 ± 0.33 0.118 25 − 0.78 ± 0.71 0.270
 RRB CSS 59 − 0.13 ± 0.25 0.612 25 0.22 ± 0.69 0.753
  1. aSemi-parametric regression adjusted for country, ADOS CSS and age for males and robust regression adjusted for ADOS CSS for females
  2. bRobust regression adjusted for country and corrected FSIQ for males and only corrected FSIQ for females; β = estimated regression coefficient; se = standard error. *p value remained < 0.05 after adjustment for multiple testing
  3. Italic values indicate significance prior to adjustment for multiple testing