Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features

Table 3 Relationship between intellectual functioning (corrected) scores and autism features, with FMR1 mRNA levels in males and females

	Males			Females
	n	β ± se	p	n	β ± se	p
Intellectual Functioning (corrected)^a
cVIQ	66	9.09 ± 3.90	0.023*	28	10.6 ± 6.18	0.087
cPIQ	67	8.71 ± 4.77	0.072	28	2.85 ± 4.68	0.543
cFSIQ	66	9.46 ± 4.24	0.029*	28	5.32 ± 4.50	0.237
Autism features^b
ADOS CSS	59	0.12 ± 0.25	0.627	25	− 8.00 ± 0.69	0.249
SA CSS	59	0.52 ± 0.33	0.118	25	− 0.78 ± 0.71	0.270
RRB CSS	59	− 0.13 ± 0.25	0.612	25	0.22 ± 0.69	0.753

^aSemi-parametric regression adjusted for country, ADOS CSS and age for males and robust regression adjusted for ADOS CSS for females
^bRobust regression adjusted for country and corrected FSIQ for males and only corrected FSIQ for females; β = estimated regression coefficient; se = standard error. *p value remained < 0.05 after adjustment for multiple testing
Italic values indicate significance prior to adjustment for multiple testing

ISSN: 2040-2392