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Table 2 Comparison between FM-only males with complete and incomplete FMR1 mRNA silencing on intellectual functioning (corrected) scores and autism features

From: Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features

  FM-only with incomplete FMR1 mRNA silencing FM-only with complete FMR1 mRNA silencing p
n M SD n M SD
Intellectual Functioninga
 cVIQ 33 37.0 26.9 21 41.5 20.4 0.196
 cPIQ 33 36.8 20.6 21 44.4 19.5 0.980
 cFSIQ 33 22.9 24.3 21 28.4 23.2 0.497
Autism features (whole sample)b
 ADOS CSS 30 7.23 1.74 20 5.90 2.29 0.041
 SA CSS 30 7.07 2.00 20 5.95 2.56 0.035
 RRB CSS 30 7.73 1.57 20 6.70 2.30 0.202
Autism features (< 19 years)b
 ADOS CSS 24 7.29 1.85 16 5.31 2.09 0.011*
 SA CSS 24 7.08 2.19 16 5.50 2.61 0.029*
 RRB CSS 24 7.83 1.66 16 6.50 2.42 0.171
Autism features (< 13 years)b
 ADOS CSS 19 7.16 1.92 13 5.31 2.18 0.050
 SA CSS 19 7.11 2.21 13 5.15 2.58 0.047
 RRB CSS 19 7.68 1.77 13 6.77 2.45 0.647
  1. aSemi-parametric regression adjusted for country, ADOS CSS and age
  2. bRobust regression adjusted for country and cFSIQ; *p value remained < 0.05 after adjustment for multiple testing
  3. Italic values indicate significance prior to adjustment for multiple testing