Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features

Table 2 Comparison between FM-only males with complete and incomplete FMR1 mRNA silencing on intellectual functioning (corrected) scores and autism features

	FM-only with incomplete FMR1 mRNA silencing			FM-only with complete FMR1 mRNA silencing			p
	n	M	SD	n	M	SD	p
Intellectual Functioning^a
cVIQ	33	37.0	26.9	21	41.5	20.4	0.196
cPIQ	33	36.8	20.6	21	44.4	19.5	0.980
cFSIQ	33	22.9	24.3	21	28.4	23.2	0.497
Autism features (whole sample)^b
ADOS CSS	30	7.23	1.74	20	5.90	2.29	0.041
SA CSS	30	7.07	2.00	20	5.95	2.56	0.035
RRB CSS	30	7.73	1.57	20	6.70	2.30	0.202
Autism features (< 19 years)^b
ADOS CSS	24	7.29	1.85	16	5.31	2.09	0.011*
SA CSS	24	7.08	2.19	16	5.50	2.61	0.029*
RRB CSS	24	7.83	1.66	16	6.50	2.42	0.171
Autism features (< 13 years)^b
ADOS CSS	19	7.16	1.92	13	5.31	2.18	0.050
SA CSS	19	7.11	2.21	13	5.15	2.58	0.047
RRB CSS	19	7.68	1.77	13	6.77	2.45	0.647

^aSemi-parametric regression adjusted for country, ADOS CSS and age
^bRobust regression adjusted for country and cFSIQ; *p value remained < 0.05 after adjustment for multiple testing
Italic values indicate significance prior to adjustment for multiple testing

ISSN: 2040-2392