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Fig. 4 | Molecular Autism

Fig. 4

From: Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?

Fig. 4

The atypical expansion of NKG2C+ NK cells in patients with hf-ASD. a The frequency of NKp46+ cells gated on CD3CD56+ NK cells in 35 ASD patients and 35 age- and sex-matched healthy controls from the French National Blood Service (EFS-Ctl), ***p < 0.0001(Mann-Whitney test). Representative samples in right panels. b The follow-up of NKp46 frequency on CD3CD56+ NK cells over a 2-year period in four hf-ASD patients. c The correlation between NKG2C and NKp46 in NK cells in 35 hf-ASD patients. d The frequency of NKG2C+ cells gated on CD3CD56+ NK cells in 35 hf-ASD patients and 35 EFS-Ctl, *p < 0.05 (Mann-Whitney test). Representative samples are shown the in right panels. e The follow-up of NKG2C frequency on CD3CD56+ NK cells over a 2-year period in four hf-ASD patients. f NKG2C expression on NK cells in CMV seronegative (n = 22) and seropositive patients (n = 13)

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