Table 3 Restored or ameliorated phenotypes in Shank3 rat models displaying the targeted domain, the experimental paradigms and drug name
From: A multifaceted approach for analyzing complex phenotypic data in rodent models of autism
Domain | Phenoterm | Experimental paradigm | Effect | Agent | Citation |
|---|---|---|---|---|---|
ANK | Reward reinforced choice behavior | Operant conditioning paradigm | Ameliorated | Oxytocin | [53] |
Social memory: long-term social memory | Reciprocal social interaction test | Ameliorated | |||
Synaptic plasticity: hippocampal LTP | Field potential recordings | Ameliorated | |||
Synaptic plasticity: mPFC LTP | In vivo local field potential (LFP) recordings | Restored |