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Table 3 Restored or ameliorated phenotypes in Shank3 rat models displaying the targeted domain, the experimental paradigms and drug name

From: A multifaceted approach for analyzing complex phenotypic data in rodent models of autism

Domain Phenoterm Experimental paradigm Effect Agent Citation
ANK Reward reinforced choice behavior Operant conditioning paradigm Ameliorated Oxytocin [53]
Social memory: long-term social memory Reciprocal social interaction test Ameliorated
Synaptic plasticity: hippocampal LTP Field potential recordings Ameliorated
Synaptic plasticity: mPFC LTP In vivo local field potential (LFP) recordings Restored