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Fig. 6 | Molecular Autism

Fig. 6

From: A multifaceted approach for analyzing complex phenotypic data in rodent models of autism

Fig. 6

Shank3 PRO domain-targeted HM KI and KO models. Phenotypic observations from Shank3 HM KI models by insertion type. ASD(insG) and Schz(R1117X) are human mutations in exon 21 found in people with ASD and schizophrenia. Social behavior is affected in ASD and Schz-related mutations, as well as exon 21 KO that causes the production of fewer Shank3 isoforms. Schz-related mutation does not cause an increase in self-grooming, unlike the InsG, including ASD-related InsG. Other learning and memory phenotypes and neurophysiological and anatomical features are affected in both ASD and Schz-specific KI mutation as well as exon 21 KOs

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