Fig. 5

Shank3 model characteristics displayed by domain targeted. a Schematic representation of the relative positions of exons (blue vertical lines) and protein domains in mouse Shank3, with numbers marking exons containing the respective domains (indicated by brackets on top). The solid horizontal black lines indicate the targeted regions in Shank3 KO mouse model constructs present in AutDB. The arrow indicates the approximate location of KI constructs, and black arrows are human mutations replicated in mouse. Relative positions of introns and exons are based on Ensembl. b This graphic depicts the most frequently assessed phenotypes of Shank3 mouse models present in our database, displayed here separately for all homozygous (HM) KOs genotypes. Each tile color represents the phenovalue and phenotypes that have been arranged in a grid by the domain targeted in the KO constructs. c Detailed view of core phenotypes of Shank3 HT and HM models based on ANK-, PDZ-, and PRO-targeted domains. This figure depicts that several core phenotypes are exhibited by HT and HM models and shows the presence of apparently contradictory data in behavioral analyses, which in some instances can be explained due to differences in age or sex of animals tested (see the main text)