TY - STD TI - Austen J. β€œIt is a truth universally acknowledged, that a single man in possession of a good fortune must be in want of a wife.” Famous first line of Pride and Prejudice (1813), by Jane Austen. Phyllis Ferguson Bottomer, author of So Odd a Mixture: Along the Autistic Spectrum in 'Pride and Prejudice' (2007), found many autistic traits in the Bennet and Fitzwilliams families. Austen wrote about them, without knowing what it was that she was describing. ID - ref1 ER - TY - JOUR AU - Constantino, J. N. AU - Charman, T. PY - 2016 DA - 2016// TI - Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression JO - Lancet Neurol VL - 15 UR - https://doi.org/10.1016/S1474-4422(15)00151-9 DO - 10.1016/S1474-4422(15)00151-9 ID - Constantino2016 ER - TY - BOOK PY - 2013 DA - 2013// TI - Diagnostic and statistical manual of mental disorders UR - https://doi.org/10.1176/appi.books.9780890425596 DO - 10.1176/appi.books.9780890425596 ID - ref3 ER - TY - JOUR AU - Woolfenden, S. AU - Sarkozy, V. AU - Ridley, G. AU - Coory, M. AU - Williams, K. PY - 2012 DA - 2012// TI - A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality JO - Dev Med Child Neurol VL - 54 UR - https://doi.org/10.1111/j.1469-8749.2012.04223.x DO - 10.1111/j.1469-8749.2012.04223.x ID - Woolfenden2012 ER - TY - JOUR AU - Schendel, D. E. AU - Overgaard, M. AU - Christensen, J. AU - Hjort, L. AU - Jorgensen, M. AU - Vestergaard, M. PY - 2016 DA - 2016// TI - Association of Psychiatric and Neurologic Comorbidity with Mortality among Persons with Autism Spectrum Disorder in a Danish population JO - JAMA Pediatr VL - 170 UR - https://doi.org/10.1001/jamapediatrics.2015.3935 DO - 10.1001/jamapediatrics.2015.3935 ID - Schendel2016 ER - TY - JOUR AU - Hirvikoski, T. AU - Mittendorfer-Rutz, E. AU - Boman, M. AU - Larsson, H. AU - Lichtenstein, P. AU - Bolte, S. PY - 2016 DA - 2016// TI - Premature mortality in autism spectrum disorder JO - Br J Psychiatry VL - 208 UR - https://doi.org/10.1192/bjp.bp.114.160192 DO - 10.1192/bjp.bp.114.160192 ID - Hirvikoski2016 ER - TY - JOUR AU - Gillberg, C. AU - Billstedt, E. AU - Sundh, V. AU - Gillberg, I. C. PY - 2010 DA - 2010// TI - Mortality in autism: a prospective longitudinal community-based study JO - J Autism Dev Disord VL - 40 UR - https://doi.org/10.1007/s10803-009-0883-4 DO - 10.1007/s10803-009-0883-4 ID - Gillberg2010 ER - TY - JOUR PY - 2017 DA - 2017// TI - Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016 JO - Lancet VL - 390 UR - https://doi.org/10.1016/S0140-6736(17)32152-9 DO - 10.1016/S0140-6736(17)32152-9 ID - ref8 ER - TY - JOUR AU - Lai, M. C. AU - Lombardo, M. V. AU - Baron-Cohen, S. PY - 2014 DA - 2014// TI - Autism JO - Lancet VL - 383 UR - https://doi.org/10.1016/S0140-6736(13)61539-1 DO - 10.1016/S0140-6736(13)61539-1 ID - Lai2014 ER - TY - JOUR AU - Lauritsen, M. B. AU - Mors, O. AU - Mortensen, P. B. AU - Ewald, H. PY - 2002 DA - 2002// TI - Medical disorders among inpatients with autism in Denmark according to ICD-8: a nationwide register-based study JO - J Autism Dev Disord VL - 32 UR - https://doi.org/10.1023/A:1014840622023 DO - 10.1023/A:1014840622023 ID - Lauritsen2002 ER - TY - JOUR AU - Chiang, H. L. AU - Liu, C. J. AU - Hu, Y. W. AU - Chen, S. C. AU - Hu, L. Y. AU - Shen, C. C. PY - 2015 DA - 2015// TI - Risk of cancer in children, adolescents, and young adults with autistic disorder JO - J Pediatr VL - 166 UR - https://doi.org/10.1016/j.jpeds.2014.10.029 DO - 10.1016/j.jpeds.2014.10.029 ID - Chiang2015 ER - TY - JOUR AU - Darbro, B. W. AU - Singh, R. AU - Zimmerman, M. B. AU - Mahajan, V. B. AU - Bassuk, A. G. PY - 2016 DA - 2016// TI - Autism linked to increased oncogene mutations but decreased Cancer rate JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0149041 DO - 10.1371/journal.pone.0149041 ID - Darbro2016 ER - TY - JOUR AU - Catala-Lopez, F. AU - Hutton, B. AU - Page, M. J. AU - Ridao, M. AU - Driver, J. A. AU - Alonso-Arroyo, A. PY - 2017 DA - 2017// TI - Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies JO - Syst Rev VL - 6 ID - Catala-Lopez2017 ER - TY - JOUR AU - Catala-Lopez, F. AU - Hutton, B. AU - Driver, J. A. AU - Page, M. J. AU - Ridao, M. AU - Valderas, J. M. PY - 2017 DA - 2017// TI - Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies JO - Syst Rev VL - 6 UR - https://doi.org/10.1186/s13643-017-0466-y DO - 10.1186/s13643-017-0466-y ID - Catala-Lopez2017 ER - TY - JOUR AU - Catala-Lopez, F. AU - Suarez-Pinilla, M. AU - Suarez-Pinilla, P. AU - Valderas, J. M. AU - Gomez-Beneyto, M. AU - Martinez, S. PY - 2014 DA - 2014// TI - Inverse and direct cancer comorbidity in people with central nervous system disorders: a meta-analysis of cancer incidence in 577,013 participants of 50 observational studies JO - Psychother Psychosom VL - 83 UR - https://doi.org/10.1159/000356498 DO - 10.1159/000356498 ID - Catala-Lopez2014 ER - TY - JOUR AU - Mouridsen, S. E. AU - Rich, B. AU - Isager, T. PY - 2016 DA - 2016// TI - Risk of cancer in adult people diagnosed with infantile autism in childhood: A longitudinal case control study based on hospital discharge diagnoses JO - Research in Autism Spectrum Disorders VL - 23 UR - https://doi.org/10.1016/j.rasd.2015.12.010 DO - 10.1016/j.rasd.2015.12.010 ID - Mouridsen2016 ER - TY - JOUR AU - Fairthorne, J. AU - Hammond, G. AU - Bourke, J. AU - Jacoby, P. AU - Leonard, H. PY - 2014 DA - 2014// TI - Early mortality and primary causes of death in mothers of children with intellectual disability or autism spectrum disorder: a retrospective cohort study JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0113430 DO - 10.1371/journal.pone.0113430 ID - Fairthorne2014 ER - TY - JOUR AU - Fairthorne, J. C. AU - Klerk, N. H. AU - Leonard, H. M. AU - Whitehouse, A. J. PY - 2016 DA - 2016// TI - Mothers of children with autism have different rates of Cancer according to the presence of intellectual disability in their child JO - J Autism Dev Disord VL - 46 UR - https://doi.org/10.1007/s10803-016-2847-9 DO - 10.1007/s10803-016-2847-9 ID - Fairthorne2016 ER - TY - STD TI - Bishop-Fitzpatrick L, Movaghar A, Greenberg JS, Page D, DaWalt LS, Brilliant MH, et al. Using machine learning to identify patterns of lifetime health problems in decedents with autism spectrum disorder. Autism Res. 2018. ID - ref19 ER - TY - JOUR AU - Oikonomakis, V. AU - Kosma, K. AU - Mitrakos, A. AU - Sofocleous, C. AU - Pervanidou, P. AU - Syrmou, A. PY - 2016 DA - 2016// TI - Recurrent copy number variations as risk factors for autism spectrum disorders: analysis of the clinical implications JO - Clin Genet VL - 89 UR - https://doi.org/10.1111/cge.12740 DO - 10.1111/cge.12740 ID - Oikonomakis2016 ER - TY - JOUR AU - Zack, T. I. AU - Schumacher, S. E. AU - Carter, S. L. AU - Cherniack, A. D. AU - Saksena, G. AU - Tabak, B. PY - 2013 DA - 2013// TI - Pan-cancer patterns of somatic copy number alteration JO - Nat Genet VL - 45 UR - https://doi.org/10.1038/ng.2760 DO - 10.1038/ng.2760 ID - Zack2013 ER - TY - JOUR AU - Tilot, A. K. AU - Bebek, G. AU - Niazi, F. AU - Altemus, J. B. AU - Romigh, T. AU - Frazier, T. W. PY - 2016 DA - 2016// TI - Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder JO - Mol Psychiatry VL - 21 UR - https://doi.org/10.1038/mp.2015.17 DO - 10.1038/mp.2015.17 ID - Tilot2016 ER - TY - JOUR AU - Wen, Y. AU - Herbert, M. R. PY - 2017 DA - 2017// TI - Connecting the dots: overlaps between autism and cancer suggest possible common mechanisms regarding signaling pathways related to metabolic alterations JO - Med Hypotheses VL - 103 UR - https://doi.org/10.1016/j.mehy.2017.05.004 DO - 10.1016/j.mehy.2017.05.004 ID - Wen2017 ER - TY - JOUR AU - Crawley, J. N. AU - Heyer, W. D. AU - LaSalle, J. M. PY - 2016 DA - 2016// TI - Autism and Cancer share risk genes, pathways, and drug targets JO - Trends Genet VL - 32 UR - https://doi.org/10.1016/j.tig.2016.01.001 DO - 10.1016/j.tig.2016.01.001 ID - Crawley2016 ER - TY - JOUR AU - Frazier, T. W. AU - Embacher, R. AU - Tilot, A. K. AU - Koenig, K. AU - Mester, J. AU - Eng, C. PY - 2015 DA - 2015// TI - Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism JO - Mol Psychiatry VL - 20 UR - https://doi.org/10.1038/mp.2014.125 DO - 10.1038/mp.2014.125 ID - Frazier2015 ER - TY - JOUR AU - Vogt, D. AU - Cho, K. K. A. AU - Lee, A. T. AU - Sohal, V. S. AU - Rubenstein, J. L. R. PY - 2015 DA - 2015// TI - The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles JO - Cell Rep VL - 11 UR - https://doi.org/10.1016/j.celrep.2015.04.019 DO - 10.1016/j.celrep.2015.04.019 ID - Vogt2015 ER - TY - JOUR AU - Smith, I. N. AU - Thacker, S. AU - Jaini, R. AU - Eng, C. PY - 2018 DA - 2018// TI - Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes JO - J Biomol Struct Dyn VL - 14 ID - Smith2018 ER - TY - JOUR AU - Kilincaslan, A. AU - Kok, B. E. AU - Tekturk, P. AU - Yalcinkaya, C. AU - Ozkara, C. AU - Yapici, Z. PY - 2017 DA - 2017// TI - Beneficial effects of Everolimus on autism and attention-deficit/hyperactivity disorder symptoms in a Group of Patients with tuberous sclerosis complex JO - J Child Adolesc Psychopharmacol VL - 27 UR - https://doi.org/10.1089/cap.2016.0100 DO - 10.1089/cap.2016.0100 ID - Kilincaslan2017 ER - TY - JOUR AU - Subramanian, A. AU - Narayan, R. AU - Corsello, S. M. AU - Peck, D. D. AU - Natoli, T. E. AU - Lu, X. PY - 2017 DA - 2017// TI - A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles JO - Cell VL - 171 UR - https://doi.org/10.1016/j.cell.2017.10.049 DO - 10.1016/j.cell.2017.10.049 ID - Subramanian2017 ER - TY - JOUR AU - Lamb, J. AU - Crawford, E. D. AU - Peck, D. AU - Modell, J. W. AU - Blat, I. C. AU - Wrobel, M. J. PY - 2006 DA - 2006// TI - The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease JO - Science VL - 313 UR - https://doi.org/10.1126/science.1132939 DO - 10.1126/science.1132939 ID - Lamb2006 ER - TY - JOUR AU - Iorio, F. AU - Bosotti, R. AU - Scacheri, E. AU - Belcastro, V. AU - Mithbaokar, P. AU - Ferriero, R. PY - 2010 DA - 2010// TI - Discovery of drug mode of action and drug repositioning from transcriptional responses JO - Proc Natl Acad Sci U S A VL - 107 UR - https://doi.org/10.1073/pnas.1000138107 DO - 10.1073/pnas.1000138107 ID - Iorio2010 ER - TY - JOUR AU - Chen, J. AU - Alberts, I. AU - Li, X. PY - 2014 DA - 2014// TI - Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders JO - Int J Dev Neurosci VL - 35 UR - https://doi.org/10.1016/j.ijdevneu.2014.03.006 DO - 10.1016/j.ijdevneu.2014.03.006 ID - Chen2014 ER - TY - JOUR AU - Martini, M. AU - Santis, M. C. AU - Braccini, L. AU - Gulluni, F. AU - Hirsch, E. PY - 2014 DA - 2014// TI - PI3K/AKT signaling pathway and cancer: an updated review JO - Ann Med VL - 46 UR - https://doi.org/10.3109/07853890.2014.912836 DO - 10.3109/07853890.2014.912836 ID - Martini2014 ER - TY - STD TI - Gene Expression Omnibus (GEO). Available at: https://www.ncbi.nlm.nih.gov/geo/. UR - https://www.ncbi.nlm.nih.gov/geo/ ID - ref34 ER - TY - STD TI - Array Express (AE). Available at: https://www.ebi.ac.uk/arrayexpress/. UR - https://www.ebi.ac.uk/arrayexpress/ ID - ref35 ER - TY - JOUR AU - Chow, M. L. AU - Winn, M. E. AU - Li, H. R. AU - April, C. AU - Wynshaw-Boris, A. AU - Fan, J. B. PY - 2012 DA - 2012// TI - Preprocessing and quality control strategies for Illumina DASL assay-based brain gene expression studies with semi-degraded samples JO - Front Genet VL - 3 UR - https://doi.org/10.3389/fgene.2012.00011 DO - 10.3389/fgene.2012.00011 ID - Chow2012 ER - TY - JOUR AU - Voineagu, I. AU - Wang, X. AU - Johnston, P. AU - Lowe, J. K. AU - Tian, Y. AU - Horvath, S. PY - 2011 DA - 2011// TI - Transcriptomic analysis of autistic brain reveals convergent molecular pathology JO - Nature VL - 474 UR - https://doi.org/10.1038/nature10110 DO - 10.1038/nature10110 ID - Voineagu2011 ER - TY - JOUR AU - Gupta, S. AU - Ellis, S. E. AU - Ashar, F. N. AU - Moes, A. AU - Bader, J. S. AU - Zhan, J. PY - 2014 DA - 2014// TI - Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism JO - Nat Commun VL - 5 UR - https://doi.org/10.1038/ncomms6748 DO - 10.1038/ncomms6748 ID - Gupta2014 ER - TY - JOUR AU - Carvalho, B. S. AU - Irizarry, R. A. PY - 2010 DA - 2010// TI - A framework for oligonucleotide microarray preprocessing JO - Bioinformatics VL - 26 UR - https://doi.org/10.1093/bioinformatics/btq431 DO - 10.1093/bioinformatics/btq431 ID - Carvalho2010 ER - TY - JOUR AU - Gautier, L. AU - Cope, L. AU - Bolstad, B. M. AU - Irizarry, R. A. PY - 2004 DA - 2004// TI - Affy---analysis of Affymetrix GeneChip data at the probe level JO - Bioinformatics VL - 20 UR - https://doi.org/10.1093/bioinformatics/btg405 DO - 10.1093/bioinformatics/btg405 ID - Gautier2004 ER - TY - STD TI - Du, P., Kibbe, W.A., Lin, S.M. lumi: a pipeline for processing Illumina microarray. Bioinformatics 2008. ID - ref41 ER - TY - JOUR AU - Ritchie, M. E. AU - Phipson, B. AU - Wu, D. AU - Hu, Y. AU - Law, C. W. AU - Shi, W. PY - 2015 DA - 2015// TI - limma powers differential expression analyses for RNA-sequencing and microarray studies JO - Nucleic Acids Res VL - 43 UR - https://doi.org/10.1093/nar/gkv007 DO - 10.1093/nar/gkv007 ID - Ritchie2015 ER - TY - JOUR AU - Love, M. I. AU - Huber, W. AU - Anders, S. PY - 2014 DA - 2014// TI - Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 JO - Genome Biol VL - 15 UR - https://doi.org/10.1186/s13059-014-0550-8 DO - 10.1186/s13059-014-0550-8 ID - Love2014 ER - TY - JOUR AU - Langfelder, P. AU - Horvath, S. PY - 2012 DA - 2012// TI - Fast R functions for robust correlations and hierarchical clustering JO - J Stat Softw VL - 46 UR - https://doi.org/10.18637/jss.v046.i11 DO - 10.18637/jss.v046.i11 ID - Langfelder2012 ER - TY - BOOK AU - Leek, J. T. AU - Johnson, W. E. AU - Parker, H. S. AU - Fertig, E. J. AU - Jaffe, A. E. AU - Storey, J. D. PY - 2017 DA - 2017// TI - sva: Surrogate Variable Analysis ID - Leek2017 ER - TY - JOUR AU - Hernandez, D. G. AU - Nalls, M. A. AU - Moore, M. AU - Chong, S. AU - Dillman, A. AU - Trabzuni, D. PY - 2012 DA - 2012// TI - Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain JO - Neurobiol Dis VL - 47 UR - https://doi.org/10.1016/j.nbd.2012.03.020 DO - 10.1016/j.nbd.2012.03.020 ID - Hernandez2012 ER - TY - JOUR AU - Trabzuni, D. AU - Ramasamy, A. AU - Imran, S. AU - Walker, R. AU - Smith, C. AU - Weale, M. E. PY - 2013 DA - 2013// TI - Widespread sex differences in gene expression and splicing in the adult human brain JO - Nat Commun VL - 4 UR - https://doi.org/10.1038/ncomms3771 DO - 10.1038/ncomms3771 ID - Trabzuni2013 ER - TY - BOOK AU - Kang, D. AU - Tseng, G. PY - 2012 DA - 2012// TI - MetaQC: MetaQC: Objective Quality Control and Inclusion/Exclusion Criteria for Genomic Meta-Analysis UR - https://doi.org/10.1093/nar/gkr1071 DO - 10.1093/nar/gkr1071 ID - Kang2012 ER - TY - JOUR AU - Sweeney, T. E. AU - Haynes, W. A. AU - Vallania, F. AU - Ioannidis, J. P. AU - Khatri, P. PY - 2017 DA - 2017// TI - Methods to increase reproducibility in differential gene expression via meta-analysis JO - Nucleic Acids Res VL - 45 UR - https://doi.org/10.1093/nar/gkw797 DO - 10.1093/nar/gkw797 ID - Sweeney2017 ER - TY - JOUR AU - Choi, J. K. AU - Yu, U. AU - Kim, S. AU - Yoo, O. J. PY - 2003 DA - 2003// TI - Combining multiple microarray studies and modeling interstudy variation JO - Bioinformatics VL - 19 UR - https://doi.org/10.1093/bioinformatics/btg1010 DO - 10.1093/bioinformatics/btg1010 ID - Choi2003 ER - TY - BOOK AU - Wang, X. AU - Li, J. AU - Tseng, G. C. PY - 2012 DA - 2012// TI - MetaDE: MetaDE: Microarray meta-analysis for differentially expressed gene detection ID - Wang2012 ER - TY - JOUR AU - Ibanez, K. AU - Boullosa, C. AU - Tabares-Seisdedos, R. AU - Baudot, A. AU - Valencia, A. PY - 2014 DA - 2014// TI - Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcriptomic meta-analyses JO - PLoS Genet VL - 10 UR - https://doi.org/10.1371/journal.pgen.1004173 DO - 10.1371/journal.pgen.1004173 ID - Ibanez2014 ER - TY - JOUR AU - Sanchez-Valle, J. AU - Tejero, H. AU - Ibanez, K. AU - Portero, J. L. AU - Krallinger, M. AU - Al-Shahrour, F. PY - 2017 DA - 2017// TI - A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's disease JO - Glioblastoma and Lung cancer Sci Rep VL - 7 ID - Sanchez-Valle2017 ER - TY - STD TI - Gene Set Enrichment Analysis (GSEA). Available at: http://software.broadinstitute.org/gsea/index.jsp. UR - http://software.broadinstitute.org/gsea/index.jsp ID - ref54 ER - TY - BOOK AU - Reimand, J. AU - Kolde, R. AU - Arak, T. PY - 2018 DA - 2018// TI - gProfileR: Interface to the 'g:Profiler' toolkit ID - Reimand2018 ER - TY - JOUR AU - Vidovic, D. AU - Koleti, A. AU - Schurer, S. C. PY - 2014 DA - 2014// TI - Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action JO - Front Genet VL - 5 ID - Vidovic2014 ER - TY - STD TI - Library of Integrated Network-based Cellular Signatures (LINCS). Available at: http://www.lincsproject.org/. UR - http://www.lincsproject.org/ ID - ref57 ER - TY - BOOK AU - Pickering, A. PY - 2017 DA - 2017// TI - ccmap: Combination Connectivity Mapping ID - Pickering2017 ER - TY - STD TI - Sergushichev A. An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation. bioRxiv. 2016. https://doi.org/10.1101/060012. ID - ref59 ER - TY - JOUR AU - Peng, L. AU - Bian, X. W. AU - Li, D. K. AU - Xu, C. AU - Wang, G. M. AU - Xia, Q. Y. PY - 2015 DA - 2015// TI - Large-scale RNA-Seq transcriptome analysis of 4043 cancers and 548 Normal tissue controls across 12 TCGA Cancer types JO - Sci Rep VL - 5 UR - https://doi.org/10.1038/srep13413 DO - 10.1038/srep13413 ID - Peng2015 ER - TY - JOUR AU - Lee, M. AU - Krishnamurthy, J. AU - Susi, A. AU - Sullivan, C. AU - Gorman, G. H. AU - Hisle-Gorman, E. PY - 2018 DA - 2018// TI - Association of Autism Spectrum Disorders and Inflammatory Bowel Disease JO - J Autism Dev Disord VL - 48 UR - https://doi.org/10.1007/s10803-017-3409-5 DO - 10.1007/s10803-017-3409-5 ID - Lee2018 ER - TY - JOUR AU - Axelrad, J. E. AU - Lichtiger, S. AU - Yajnik, V. PY - 2016 DA - 2016// TI - Inflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatment JO - World J Gastroenterol VL - 22 UR - https://doi.org/10.3748/wjg.v22.i20.4794 DO - 10.3748/wjg.v22.i20.4794 ID - Axelrad2016 ER - TY - JOUR AU - Qin, L. AU - Ma, K. AU - Wang, Z. J. AU - Hu, Z. AU - Matas, E. AU - Wei, J. PY - 2018 DA - 2018// TI - Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition JO - Nat Neurosci VL - 21 UR - https://doi.org/10.1038/s41593-018-0110-8 DO - 10.1038/s41593-018-0110-8 ID - Qin2018 ER - TY - JOUR AU - Kataoka, S. AU - Takuma, K. AU - Hara, Y. AU - Maeda, Y. AU - Ago, Y. AU - Matsuda, T. PY - 2013 DA - 2013// TI - Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid JO - Int J Neuropsychopharmacol VL - 16 UR - https://doi.org/10.1017/S1461145711001714 DO - 10.1017/S1461145711001714 ID - Kataoka2013 ER - TY - JOUR AU - Glozak, M. A. AU - Seto, E. PY - 2007 DA - 2007// TI - Histone deacetylases and cancer JO - Oncogene VL - 26 UR - https://doi.org/10.1038/sj.onc.1210610 DO - 10.1038/sj.onc.1210610 ID - Glozak2007 ER - TY - JOUR AU - Li, Z. AU - Zhu, W. G. PY - 2014 DA - 2014// TI - Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications JO - Int J Biol Sci VL - 10 UR - https://doi.org/10.7150/ijbs.9067 DO - 10.7150/ijbs.9067 ID - Li2014 ER - TY - JOUR AU - Zheng, Q. AU - Huang, T. AU - Zhang, L. AU - Zhou, Y. AU - Luo, H. AU - Xu, H. PY - 2016 DA - 2016// TI - Dysregulation of ubiquitin-proteasome system in neurodegenerative diseases JO - Front Aging Neurosci VL - 8 UR - https://doi.org/10.3389/fnagi.2016.00303 DO - 10.3389/fnagi.2016.00303 ID - Zheng2016 ER - TY - JOUR AU - Manasanch, E. E. AU - Orlowski, R. Z. PY - 2017 DA - 2017// TI - Proteasome inhibitors in cancer therapy JO - Nat Rev Clin Oncol VL - 14 UR - https://doi.org/10.1038/nrclinonc.2016.206 DO - 10.1038/nrclinonc.2016.206 ID - Manasanch2017 ER - TY - JOUR AU - Kern, J. K. AU - Geier, D. A. AU - Sykes, L. K. AU - Geier, M. R. PY - 2016 DA - 2016// TI - Relevance of Neuroinflammation and encephalitis in autism JO - Front Cell Neurosci VL - 9 UR - https://doi.org/10.3389/fncel.2015.00519 DO - 10.3389/fncel.2015.00519 ID - Kern2016 ER - TY - JOUR AU - Pardo, C. A. AU - Vargas, D. L. AU - Zimmerman, A. W. PY - 2005 DA - 2005// TI - Immunity, neuroglia and neuroinflammation in autism JO - Int Rev Psychiatry VL - 17 UR - https://doi.org/10.1080/02646830500381930 DO - 10.1080/02646830500381930 ID - Pardo2005 ER - TY - JOUR AU - Vargas, D. L. AU - Nascimbene, C. AU - Krishnan, C. AU - Zimmerman, A. W. AU - Pardo, C. A. PY - 2005 DA - 2005// TI - Neuroglial activation and neuroinflammation in the brain of patients with autism JO - Ann Neurol VL - 57 UR - https://doi.org/10.1002/ana.20315 DO - 10.1002/ana.20315 ID - Vargas2005 ER - TY - JOUR AU - Zimmerman, A. W. AU - Jyonouchi, H. AU - Comi, A. M. AU - Connors, S. L. AU - Milstien, S. AU - Varsou, A. PY - 2005 DA - 2005// TI - Cerebrospinal fluid and serum markers of inflammation in autism JO - Pediatr Neurol VL - 33 UR - https://doi.org/10.1016/j.pediatrneurol.2005.03.014 DO - 10.1016/j.pediatrneurol.2005.03.014 ID - Zimmerman2005 ER - TY - JOUR AU - Morgan, J. T. AU - Chana, G. AU - Pardo, C. A. AU - Achim, C. AU - Semendeferi, K. AU - Buckwalter, J. PY - 2010 DA - 2010// TI - Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism JO - Biol Psychiatry VL - 68 UR - https://doi.org/10.1016/j.biopsych.2010.05.024 DO - 10.1016/j.biopsych.2010.05.024 ID - Morgan2010 ER - TY - JOUR AU - Tetreault, N. A. AU - Hakeem, A. Y. AU - Jiang, S. AU - Williams, B. A. AU - Allman, E. AU - Wold, B. J. PY - 2012 DA - 2012// TI - Microglia in the cerebral cortex in autism JO - J Autism Dev Disord VL - 42 UR - https://doi.org/10.1007/s10803-012-1513-0 DO - 10.1007/s10803-012-1513-0 ID - Tetreault2012 ER - TY - JOUR AU - Okada, F. PY - 2014 DA - 2014// TI - Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms JO - Yonago Acta Med VL - 57 ID - Okada2014 ER - TY - JOUR AU - Coussens, L. M. AU - Werb, Z. PY - 2002 DA - 2002// TI - Inflammation and cancer JO - Nature VL - 420 UR - https://doi.org/10.1038/nature01322 DO - 10.1038/nature01322 ID - Coussens2002 ER - TY - JOUR AU - Rossignol, D. A. AU - Frye, R. E. PY - 2012 DA - 2012// TI - Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis JO - Mol Psychiatry VL - 17 UR - https://doi.org/10.1038/mp.2010.136 DO - 10.1038/mp.2010.136 ID - Rossignol2012 ER - TY - JOUR AU - Markkanen, E. n. n. i. AU - Meyer, U. r. s. AU - Dianov, G. r. i. g. o. r. y. PY - 2016 DA - 2016// TI - DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond JO - International Journal of Molecular Sciences VL - 17 UR - https://doi.org/10.3390/ijms17060856 DO - 10.3390/ijms17060856 ID - Markkanen2016 ER - TY - JOUR AU - Paul, A. AU - Crow, M. AU - Raudales, R. AU - He, M. AU - Gillis, J. AU - Huang, Z. J. PY - 2017 DA - 2017// TI - Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity JO - Cell VL - 171 UR - https://doi.org/10.1016/j.cell.2017.08.032 DO - 10.1016/j.cell.2017.08.032 ID - Paul2017 ER - TY - STD TI - Ashton TM, McKenna WG, Kunz-Schughart LA, Higgins GS. Oxidative phosphorylation as an emerging target in cancer therapy. Clin Cancer Res. 2018. ID - ref80 ER - TY - STD TI - van Horssen J, van Schaik P, Witte M. Inflammation and mitochondrial dysfunction: a vicious circle in neurodegenerative disorders? Neurosci Lett. 2017. ID - ref81 ER - TY - JOUR AU - Efeyan, A. AU - Sabatini, D. M. PY - 2010 DA - 2010// TI - mTOR and cancer: many loops in one pathway JO - Curr Opin Cell Biol VL - 22 UR - https://doi.org/10.1016/j.ceb.2009.10.007 DO - 10.1016/j.ceb.2009.10.007 ID - Efeyan2010 ER - TY - JOUR AU - Mendoza, M. C. AU - Er, E. E. AU - Blenis, J. PY - 2011 DA - 2011// TI - The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation JO - Trends Biochem Sci VL - 36 UR - https://doi.org/10.1016/j.tibs.2011.03.006 DO - 10.1016/j.tibs.2011.03.006 ID - Mendoza2011 ER - TY - JOUR AU - Onore, C. AU - Yang, H. AU - Water, J. AU - Ashwood, P. PY - 2017 DA - 2017// TI - Dynamic Akt/mTOR signaling in children with autism Spectrum disorder JO - Front Pediatr VL - 5 UR - https://doi.org/10.3389/fped.2017.00043 DO - 10.3389/fped.2017.00043 ID - Onore2017 ER - TY - JOUR AU - Enriquez-Barreto, L. AU - Morales, M. PY - 2016 DA - 2016// TI - The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia JO - Mol Cell Ther VL - 4 UR - https://doi.org/10.1186/s40591-016-0047-9 DO - 10.1186/s40591-016-0047-9 ID - Enriquez-Barreto2016 ER - TY - JOUR AU - Nicolini, C. AU - Ahn, Y. AU - Michalski, B. AU - Rho, J. M. AU - Fahnestock, M. PY - 2015 DA - 2015// TI - Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid JO - Acta Neuropathol Commun VL - 3 UR - https://doi.org/10.1186/s40478-015-0184-4 DO - 10.1186/s40478-015-0184-4 ID - Nicolini2015 ER - TY - JOUR AU - Fruman, D. A. AU - Rommel, C. PY - 2014 DA - 2014// TI - PI3K and cancer: lessons, challenges and opportunities JO - Nat Rev Drug Discov VL - 13 UR - https://doi.org/10.1038/nrd4204 DO - 10.1038/nrd4204 ID - Fruman2014 ER - TY - JOUR AU - Hawkins, P. T. AU - Stephens, L. R. PY - 2015 DA - 2015// TI - PI3K signalling in inflammation JO - Biochim Biophys Acta VL - 1851 UR - https://doi.org/10.1016/j.bbalip.2014.12.006 DO - 10.1016/j.bbalip.2014.12.006 ID - Hawkins2015 ER - TY - JOUR AU - Stark, A. K. AU - Sriskantharajah, S. AU - Hessel, E. M. AU - Okkenhaug, K. PY - 2015 DA - 2015// TI - PI3K inhibitors in inflammation, autoimmunity and cancer JO - Curr Opin Pharmacol VL - 23 UR - https://doi.org/10.1016/j.coph.2015.05.017 DO - 10.1016/j.coph.2015.05.017 ID - Stark2015 ER - TY - JOUR AU - Cerniglia, G. J. AU - Dey, S. AU - Gallagher-Colombo, S. M. AU - Daurio, N. A. AU - Tuttle, S. AU - Busch, T. M. PY - 2015 DA - 2015// TI - The PI3K/Akt pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1alpha phosphorylation JO - Mol Cancer Ther VL - 14 UR - https://doi.org/10.1158/1535-7163.MCT-14-0888 DO - 10.1158/1535-7163.MCT-14-0888 ID - Cerniglia2015 ER - TY - JOUR AU - Altomare, D. A. AU - Khaled, A. R. PY - 2012 DA - 2012// TI - Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling JO - Curr Med Chem VL - 19 UR - https://doi.org/10.2174/092986712801661130 DO - 10.2174/092986712801661130 ID - Altomare2012 ER - TY - JOUR AU - Reilly, J. AU - Gallagher, L. AU - Chen, J. L. AU - Leader, G. AU - Shen, S. PY - 2017 DA - 2017// TI - Bio-collections in autism research JO - Mol Autism VL - 8 UR - https://doi.org/10.1186/s13229-017-0154-8 DO - 10.1186/s13229-017-0154-8 ID - Reilly2017 ER - TY - JOUR AU - Masi, A. AU - DeMayo, M. M. AU - Glozier, N. AU - Guastella, A. J. PY - 2017 DA - 2017// TI - An overview of autism Spectrum disorder, Heterogeneity and Treatment Options JO - Neurosci Bull VL - 33 UR - https://doi.org/10.1007/s12264-017-0100-y DO - 10.1007/s12264-017-0100-y ID - Masi2017 ER - TY - JOUR AU - Brown, E. A. AU - Lautz, J. D. AU - Davis, T. R. AU - Gniffke, E. P. AU - VanSchoiack, A. A. W. AU - Neier, S. C. PY - 2018 DA - 2018// TI - Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models JO - Mol Autism VL - 9 UR - https://doi.org/10.1186/s13229-018-0229-1 DO - 10.1186/s13229-018-0229-1 ID - Brown2018 ER -