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Fig. 5 | Molecular Autism

Fig. 5

From: The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice

Fig. 5

CLARITY reveals differences in axonal alignment and fibre density in Nrxn2α KO mice. ac Representative images of the CLARITY-treated brain, with ROI defined for the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), basomedial amygdala (BMA) and basolateral amygdala (BLA). For the ACC, the axonal alignment (d) and axon density (e) were significantly altered in KO mice, but cell density was unaltered (f). Within the medial OFC, only axonal alignment was significantly altered in KOs (g), with axon density (h) and cell density (i) being similar. For the BMA, both the axonal alignment (j) and axon density (k) were significantly increased, while cell density was unaltered (l). *p < 0.05, **p < 0.01. Error bars represent s.e.m. Wild type n = 6, Nrxn2α KO n = 6

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